Journal Highlight: Quantification of magnetic resonance spectroscopy signals with lineshape estimation

Quantification of magnetic resonance spectroscopy signals with lineshape estimation
Journal of Chemometrics
Volume 25, Issue 4, pages 183-192, April 2011
M. I. Osorio-Garcia, D. M. Sima, F. U. Nielsen, U. Himmelreich and S. Van Huffel

Quantification of magnetic resonance spectroscopy (MRS) signals is required for providing metabolite concentrations of the tissue under investigation. However, inhomogeneities of the static magnetic field and tissue heterogeneities affect the lineshape of MRS signals and thus quantification. We propose an extension of the self-deconvolution method, by estimating and smoothing a common lineshape using a robust method with local regression. This common lineshape is imposed in the metabolite quantification method and the spectral parameters are obtained via nonlinear least squares.

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