Chemometrics & Informatics / Ezine
Toxic shock
Date: Jun 15, 2009
Author: David Bradley
A correlation between the different factors affecting the toxicity of wastes hazardous to the aquatic environment can be derived from a novel battery of bioassays using multivariate analysis, primarily Principal Component Analysis, according to a new study.
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Rank annihilation factor analysis for multicomponent kinetic-spectrophotometric determination using difference spectra
Date: May 20, 2009
Author:
In this work a theoretical formulation of difference spectra for kinetic-spectrophotometric two-way data of parallel complexation reactions is presented.
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Clinical looking glass
Date: May 15, 2009
Author: David Bradley
Clinical research studies into drug efficacy and side effects have often been laborious and time consuming, new software that analyses "anonymised" patient electronic medical records could reduce investigation times from months to minutes.
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State-dependent correlations of biochemical variables in plants
Date: Apr 21, 2009
Author:
Distributions of biochemical variables in plant foliage are mainly similar to normal distributions. In this paper, the authors show that the distinction of plant physiological and/or stress states from each other can be more effective by using the correlation of biochemical variables for their characterizations than by separately statistical comparisons of means of the variables.
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ET's aminos
Date: Apr 15, 2009
Author: David Bradley
One of biology's unanswered questions involves the evolution of the genetic code and the fact it uses just 20 natural amino acids as its building blocks for making proteins. A mathematical analysis of biochemistry by researchers in Canada suggests a possible answer that could have profound implications for our search for life on other planets.
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A fully robust PARAFAC method for analyzing fluorescence data
Date: Mar 24, 2009
Author:
Parallel factor analysis (PARAFAC) is a widespread method for modeling fluorescence data by means of an alternating least squares procedure. Consequently, the PARAFAC estimates are highly influenced by outlying excitation-emission landscapes and element-wise outliers, like for example Raman and Rayleigh scatter. In this paper, the authors present an iterative algorithm where the robust PARAFAC method and the scatter identification tool are alternately performed.
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Bristling nano balls
Date: Mar 15, 2009
Author: David Bradley
A mathematical analysis of inorganic nanoparticles explains why they form complex structures with a layer of hydrophilic polymer chains.
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Contrasting tumours
Date: Feb 15, 2009
Author: David Bradley
US scientists have successfully predicted the outcome on breast tumours in a pre-clinical study of a so-called nano drug. Their research could help determine which patients will respond best to these and other drugs.
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Chemometric and statistical analyses of ToF-SIMS spectra of increasingly complex biological samples
Date: Jan 23, 2009
Author:
This study demonstrates the strength of the combination of ToF-SIMS and multivariate analysis to classify increasingly complex biological samples.
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Abnormal salivary proteins in autism
Date: Jan 15, 2009
Author: David Bradley
A saliva test for autism spectrum disorder (ASD) is being developed by researchers in Italy. Their test involves a sophisticated mass spectrometric analysis and associated statistical analysis of the data. It could provide researchers with a useful biomarker approach for a subgroup of ASD patients.
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