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Journal Highlight: Elimination of matrix interferences in GC-MS analysis of pesticides by entropy minimization

Date: Aug 14, 2017

Author: spectroscopyNOW

An entropy minimization technique that can eliminate the need for comprehensive preprocessing steps has been developed to detect organophosphorus pesticides in a fortified orange juice sample by GC/MS.

Read More thumbnail image: Journal Highlight Elimination of matrix interferences in GC-MS analysis of pesticides by entropy minimization

Hydrophilic interactions change along with volume fractions

Date: Aug 1, 2017

Author: Ryan De Vooght-Johnson

Hydrophilic interaction liquid chromatography (HILIC) is a relatively new method, so theoretical work on the relationships between its parameters is not as extensive as with older techniques. Scientists from the University of Belgrade looked at the association between peak retention and mobile phase composition for HILIC on the antipsychotic drug olanzapine and its impurities using various theoretical models.

Read More thumbnail image: Hydrophilic interactions change along with volume fractions

Journal Highlight: Determination of cannabinoids in hemp nut products in Taiwan by HPLC-MS/MS coupled with chemometric analysis: quality evaluation and a pilot human study

Date: Jul 17, 2017

Author: spectroscopyNOW

The Δ9-tetrahydrocannabinol, cannabidiol and cannabinol contents of concentrated hemp powdered nut products were determined by LC/MS using hierarchical clustering analysis and principal component analysis.

Read More thumbnail image: Journal Highlight Determination of cannabinoids in hemp nut products in Taiwan by HPLC-MSMS coupled with chemometric analysis quality evaluation and a pilot human study

Weighing up ways of working out log P

Date: Jul 15, 2017

Author: Ryan De Vooght-Johnson

Lipophilicity is a key parameter affecting the activity of potential drug molecules, but there are many methods to calculate it. Scientists from the University of Belgrade examined various techniques for calculating the lipophilicity of a number of benzothiepino[3,2-c]pyridine derivatives, which were potential antifungal drugs.

Read More thumbnail image: Weighing up ways of working out log P

Ad hoc landfill: PARAFAC of pollution risk

Date: Jul 15, 2017

Author: David Bradley

Simple landfills in developing countries represent a threat to soil and groundwater through toxic leachate. Soil column experiments to simulate pollution have been assessed using PARAFAC modelling of three-dimensional excitation-emission fluorescence to evaluate the specific risks.

Read More thumbnail image: Ad hoc landfill PARAFAC of pollution risk

DEREK peers at plethora of products in rat urine

Date: Jul 1, 2017

Author: Ryan De Vooght-Johnson

Fluvastatin is a commonly used statin compound, so it is important to carefully study its metabolites. Researchers based at the National Institutes of Pharmaceutical Education and Research in Hyderabad and S.A.S Nagar examined the metabolites of fluvastatin formed in vivo by rats, along with those formed in vitro by human or rat liver microsomes, using UHPLC-MS/MS. They subsequently ran in silico toxicity studies on these compounds.

Read More thumbnail image: DEREK peers at plethora of products in rat urine

From heartbreak to happiness with in-house MS database

Date: Jun 15, 2017

Author: Ryan De Vooght-Johnson

Gelsemium elegans is a toxic plant of interest for its possible medical uses. Scientists from Hunan Agricultural University in China used a combination of LC-MS/MS and an in-house database of the accurate masses of previously detected Gelsemium compounds to tentatively identify a wide range of the many components in a crude extract from the plant.

Read More thumbnail image: From heartbreak to happiness with in-house MS database

Precisely helium: Single molecule calibration

Date: Jun 15, 2017

Author: David Bradley

Researchers from Aarhus University in Denmark and the Institute of Science and Technology in Austria have developed a new technique for aligning molecules using lasers and ultracold droplets of helium so they can precisely measure alignment.

Read More thumbnail image: Precisely helium Single molecule calibration

Journal Highlight: Alzheimer disease classification using KPCA, LDA, and multi-kernel learning SVM

Date: Jun 12, 2017

Author: spectroscopyNOW

A novel diagnosis method for distinguishing Alzheimer disease, mild cognitive impairment and healthy states used kernel PCA followed by LDA and a a multi-kernel SVM for training and testing for detection.

Read More thumbnail image: Journal Highlight Alzheimer disease classification using KPCA LDA and multi-kernel learning SVM

Viagra cheats exposed by TLC

Date: Jun 1, 2017

Author: Ryan De Vooght-Johnson

Health supplements in some countries are frequently adulterated with PDE5 inhibitors, such as sildenafil (Viagra) or unapproved analogues. Researchers from Tianjin University of Science and Technology in China used a combination of TLC and Raman spectroscopy for the rapid identification of these pharmaceutical products in supplement samples.

Read More thumbnail image: Viagra cheats exposed by TLC
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