Previous Webinars
Improving Data Quality in ICP-MS
In the first webinar of this series, Ed McCurdy and Steve Wilbur assess the fundamental performance of He mode in removing spectral interferences in ICP-MS, thereby making such qualifier ions available for evaluation of data quality. In second webinar Ed and Steve present data demonstrating the use of qualifier ions to improve ICP-MS data quality in complex sample matrices, by confirming the measured result from the primary isotopes.
- Part 1: Basics of HPLC Method Development
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- Part 2: Automated HPLC Method Development
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Ultra High Performance LC/MS
This seminar describes the power of integrated UHPLC, fast-scanning mass specs, and uniquely powerful application software to provide clearly better solutions for food, pharmaceutical, proteomic and metabolomic analyses.
How to Increase Lab Performance with Agilent Ultra High Pressure Valve Solutions - Reducing the Time for Developing Optimal Methods
In this event, Dr. Mattias Pursch (Technology Leader, Liquid Chromatography, Dow Chemical) highlight the implementation of rapid method development using automated column and solvent screening for practical applications of industrial LC separations. Dr. Michael Frank (Product Manager, Agilent Technologies) further the discussion on automated method development by introducing the latest developments including utilizing the new Agilent 1290 Infinity LC system for additional LC capabilities to achieve infinite separation conditions.
He Mode Interference Removal for Spectral Clarity and Multi-Isotope Confirmation
The contribution that collision/reaction cells (CRC) can make to improving ICP-MS data quality by removing spectral interferences has been well documented. Similarly the potential for data quality to be degraded by the creation of new interferences or the loss of analyte sensitivity by reaction has also been widely discussed. However, the use of an inert cell gas (helium mode) and interference removal using kinetic energy discrimination (KED) not only avoids these problems, but also has the added benefit that it can effectively remove any polyatomic interference, rather than being suitable only for interferences which react with the chosen cell gas. This avoids the issue of incomplete removal of unreactive interferences, and allows helium (He) mode to be considered as a "universal" cell mode, being applied to almost all analytes in virtually any sample type.
Latest Advances in HPLC & UHPLC: The Last Word
Are you asked to save solvents, go for more sensitivity or higher resolution?
Join our panelist discussion of the latest LC technologies and what this means to you as a chromatographer or mass spectrometrist. Introducing the Agilent 1290 Infinity LC.
Your answer is finally here.
Redefining ICP-MS Analysis; Higher Matrix Levels, Simpler Operation; Better Removal of Interferences:
The Extraordinary New 7700 Series ICP-MS
After 20 years, ICP-MS technology has reached a stage of development where improvements are incremental, rather than revolutionary. Nevertheless, there were aspects of existing instrumentation where performance could clearly be improved, such as increasing matrix tolerance, improving the removal of interferences, and simplifying routine operation. All of these areas have been the focus of research and development at Agilent Technologies, leading to the introduction of the 7700 Series, the most significant new ICP-MS product launch for many years.
This live online seminar provides a comprehensive introduction to the very latest ICP-MS developments, as embodied in the 7700 Series ICP-MS; brand new technology which redefines the way routine and research labs do ICP-MS, introducing unparalleled performance, from the smallest commercial ICP-MS ever made.
Pharmaceuticals and Personal Care Products in Water, Soil, Sediment, and Biosolids by HPLC/MS/MS - EPA Method 1694
This complimentary seminar focuses on the utilization of HPLC/MS/MS within EPA Method 1694 guidelines. Since the discovery of persistent pharmaceuticals in wastewater and their widespread occurrence, numerous papers have appeared on the analysis of these compounds. EPA has established a method, EPA 1694, to evaluate these compounds in many environmental matrices. We have tested this EPA method and report on our results. Thus, an analytical methodology for screening and confirming the presence of 74 pharmaceuticals in water samples was developed using a triple quadrupole mass spectrometer. The method was developed following the guidelines in EPA Method 1694. Four distinct chromatographic gradients and LC conditions were used according to the polarity and extraction of the different pharmaceuticals. Positive and negative ion electrospray were used with two MRM transitions (a quantifier and a qualifier ion for each compound), which adds extra confirmation in this methodology compared with the EPA method. Linearity of response of 3 orders of magnitude was demonstrated (r2 > 0.99) for all the pharmaceuticals studied. The analytical performance of the method was evaluated for one wastewater sample collected in Boulder Creek, Colorado; positive identifications for carbamazepine and diphenhydramine were found for this sample using the methodology developed in this work. This study is a valuable indicator of the potential of the QqQ for routine quantitative multi-residue analysis of pharmaceuticals in water and wastewater samples.
Attendees will benefit from this live session, which presents the results of using HPLC/MS/MS to meet EPA Method 1694 guidelines.
Tripling productivity with ICP-MS - Innovative Optimization Techniques
From a performance standpoint (sensitivity, accuracy, linearity), ICP-MS is the undisputed technique of choice for elemental analysis in most applications. However, for applications which don't require state of the art performance, ICP-OES typically has an advantage in productivity in terms of samples run per day. The factors which have constrained the productivity of ICP-MS have included diluting samples to accommodate limited dissolved solids tolerance, gas switching and stabilization times for collision/reaction cell instruments and inefficient sample uptake and rinseout systems. By systematically addressing each of these limitations, Agilent has been able to reduce the typical run to run time for collision cell ICP-MS from 5-6 minutes per sample to a minute or less without adversely impacting the performance. Discussion of the various optimization techniques with example applications and results will be included.
Attendees will benefit from this live discussion with one of Agilent's ICP-MS Specialists. Hear our expert offer best practices in ICP-MS to help you achieve better results in less time.
Advances in HPLC Method Development: 3 Steps to the Best HPLC Methods
Developing the 'best' LC method is often a complex task that requires skill and patience. New techniques and technologies are available to aid in streamlining the process of developing an LC separations method thereby reducing the necessary trial and error analyses.
This live, on-line series offers three steps to creating the 'best' methods and focuses upon the core fundamentals in method development, choosing appropriate stationary phases, and automating method development in your lab saving significant time and effort.
After attending these educational sessions on method development, developing your own 'best' method is just one LC analysis away!.
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Part 1: Basics of HPLC Method Development
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Part 2: Automated HPLC Method Development
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- Part 3: Advances in HPLC Column Technologies
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Got Mass? Fast LC and LC/MS: Answers to your lab's demanding questions
This complimentary 3-part seminar series focuses on utilizing RRLC with Single Quad, Triple Quad and TOF mass spectrometry, highlighting the advantages of using sub-two micron particle technology for high resolution, fast chromatography coupled to mass spectrometers with the latest technological advances. In addition, the large data pools generated from fast analysis requires significant time for data review. Automated data analysis software accompanying the latest instrument technologies will be illustrated for the transition of great data into great discoveries.
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Part 1: High-Throughput Simultaneous Qualitative and Quantitative Analysis: Achieving Optimum Results
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Part 2: Accuracy for the masses: pushbutton sub-ppm mass accuracy for small molecules
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Part 3: Development of Triple Quadrupole methods for forensic analysis of drugs of abuse in blood and oral fluid
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Best Practices and Practical Tips for Rapid Resolution LC
This complimentary 3-part series is an excellent resource for all LC scientists. The seminar series offers valuable technical content and shows you how to get LC separations better, faster and easier.
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Part 1: Column Technology for High Throughput LC-MS Analysis of Drug-Like Compounds:
Monolithic Silica vs. Sub-2mm Packed Eclipse XDB-C18
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Part 2: Applications of Fast and Ultra-Fast Chromatography in Drug Discovery
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Part 3: Good Separation Makes for Good Mass Spectrometry
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Utilizing Sub-2µm Particles to Optimize HPLC Methods
This complimentary four part series is an excellent resource for any LC scientist. The on-demand event is a must for all who want LC separations better, faster and easier.
After completing this workshop, you will be able to:
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Quickly develop HPLC methods using isocratic or gradient conditions with a thorough look at pH, bonded phase, mobile phase, temperature and particle size effects on resolution and speed.
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Better manage assets through dramatically reduced run time and much lower mobile phase consumption.
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Properly understand the role of pressure that arises with new column technology.
This technical resource gives you the tools to increase efficiency and speed in your lab workflow by 3 - 20 times compared to conventional 5 micron and 3 micron particle technology.
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