Proteomics Ezine
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Capillary isoelectric focusing (cIEF) techniques are used for the analysis of monoclonal antibody charge heterogeneity, and imaged cIEF is a fast, robust, high-resolution alternative to IEC for this application...
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Latest Proteomics News
Monthly Highlight
Induction of a pluripotent state in somatic cells through nuclear reprogramming has ushered in a new era of regenerative medicine. However, heterogeneity and varied differentiation potentials among induced pluripotent stem cell (iPSC) lines challenge our ability to identify and isolate functionally defined cell populations for disease modeling, drug discovery, and patient therapies. Thus, there is an urgent need to develop non-genetic methods for isolating more homogeneous, functionally defined iPSCs.
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Mass Spectrometry Blog
Monthly Highlight
Traditionally, targeted peptide quantification studies have used a triple quadrupole (QQQ) mass spectrometer because of their high throughput capabilities and high sensitivity, allowing for large numbers of proteins to be quantified in a single LC/MS experiment. However, the transition from discovery to targeted verification and quantification can still be slow and cumbersome due to the transition between different mass spectrometer platforms.
In this webinar, new approaches to peptide-targeted quantification using high-resolution and accurate mass (HR/AM) mass spectrometry are introduced, together with the new Q Exactive high-performance benchtop quadrupole-Orbitrap LC-MS/MS.
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