Two-dimensional J-resolved NMR spectroscopy: review of a key methodology in the metabolomics toolbox
[registered users only]
Two-dimensional
1H
J-resolved (JRES) NMR spectroscopy is widely used in metabolomics studies of plants and animals. This review provides a basic introduction to the technique and then discusses and recommends key strategies for both spectral acquisition and processing. Strategies for implementing JRES spectroscopy into the metabolomics toolbox are then considered, including for metabolic fingerprinting, metabolite identification and metabolite quantification.
[February 3, 2010]
The long and the long of it
A novel NMR technique has measured the largest distance between two atomic nuclei using NMR, demonstrating that tritium magic angle spinning NMR could be a promising tool for structural applications in the biological and material sciences.
[February 1, 2010]
Detailed, superficial approach to finding new drugs
An international team has used NMR spectroscopy to study neglected regions of key cell-surface proteins. They have found that these regions undergo minute conformational changes in response to drugs, a finding that could ultimately prove useful in the design of new drugs for a range of diseases.
[January 15, 2010]
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