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New biomarkers in pancreatic cancer have been identified that can predict the likelihood of short-term survival of patients receiving gemcitabine therapy, earmarking those who will gain no benefit from the treatment. [February 1, 2010] |
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Advances in genomic and proteomic technologies and the molecular and genomic tools for functional analysis are reviewed in the context of using evolutionary data to make predictions about interactions among reproductive proteins. [January 25, 2010] |
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A series of biomarkers for acute kidney transplant rejection has been identified in urine by mass spectrometry and cross-validated by ELISA, establishing the basis for the serial, rapid, non-invasive monitoring of graft rejection. [January 15, 2010] |
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A new biomarker for CJD has been identified in cerebrospinal fluid by European scientists. Elevated levels of ubiquitin can lead to the correct diagnosis of cases where other established protein markers fail. [January 4, 2010] |
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A review of soil proteomics is provided by looking at the methodologies used in order to illustrate the challenges and gaps in this field, and to provide a broad perspective about the use and meaning of soil metaproteomics. [December 21, 2009] |
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Cascade affinity separation using a series of affinity ligands has been used to fractionate the proteins in mouse testis for mass spectrometric analysis. It led to the largest proteome database to date for this type of tissue. [December 15, 2009] |
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The proteomic analysis of blood from patients infected with two common malaria parasites has identified about 100 proteins, including known drug targets and potential new ones that have not been detected in reported studies using lab cultures. [December 1, 2009] |
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The potential applications of the proteomics approach in studying lung-related diseases and biomarker discovery have been reviewed. [November 23, 2009] |
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A preliminary proteomics study on the serum of veal calves by MALDI TOFMS has revealed that one particular protein fragment is indicative of treatment with illegal drugs, although more biomarkers are necessary for absolute confirmation. [November 13, 2009] |
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The wound exudates produced by the injection of two snake venom toxins into mice display contrasting proteomic profiles, illustrating the different mechanisms of tissue damage at play, say American researchers. [November 1, 2009] |
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Recent advances are reviewed that fulfil the criteria for clinical proteomics with the focus on cellular proteomics (cytoproteomics) as related to preanalytical and analytical standardization and to quality control measures required for their effective implementation into routine laboratory testing to generate novel actionable health information. [October 26, 2009] |
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A panel of 4 proteins that can predict dry eye syndrome with an accuracy of 96% has been identified in human tears, with a subset that are associated with inflammation successfully classifying the clinical severity of the condition. [October 15, 2009] |
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Inhalation of mustard gas changes the proteomic profile of bronchoalveolar lavage fluid, say Iranian researchers, who examined long-term casualties exposed during the Iran-Iraq war. The altered profile will aid attempts to identify therapeutic targets for mustard gas-induced lung disease. [October 1, 2009] |
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This review assesses the impact of transcriptomics, proteomics and metabolomics on fungal plant pathology over the last decade and discusses their futures. Key examples highlighting the application of these technologies to fungal plant pathogens are also reviewed. [September 28, 2009] |
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A set of novel protein labelling dyes, evaluated for 1D and 2D gel electrophoresis on human skin proteins, performed better than standard post-electrophoresis staining, increasing the number of spots detected and providing better sensitivity. [September 15, 2009] |
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The administration of recombinant human growth hormone to humans can be accomplished using a panel of six protein ions identified by MALDI MS or six peptide ions identified by LC/MS, say researchers in the UK. Their study combined proteomics with artificial neural networks in the first study of its type in biomarker discovery. [September 1, 2009] |
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The seed storage proteome of the non-model species (Trifolium subterraneum), was characterised in mature dry seeds and during imbibition using two-dimensional electrophoresis coupled with tandem mass spectrometry. [August 24, 2009] |
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Specific brain proteins modified by lipid peroxidation products in a region-specific manner have been identified in Alzheimer's disease patients. The two regions examined are highly susceptible, linking oxidative damage to neurodegeneration. [August 15, 2009] |
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The allergen contents of different varieties of peanut have been compared by proteomics techniques, revealing the existence of hitherto unreported fragments of major allergens. Indonesian nuts were found to contain lower amounts of major allergens, which has implications for food production. [August 1, 2009] |
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The nacre matrix of the cephalopod Nautilus macromphalus has been biochemically characterized, in part by a proteomic approach applied to the acetic acid-soluble and -insoluble shell matrices and the spots obtained after 2D gel electrophoresis. Most of the obtained partial sequences are entirely new. [July 27, 2009] |
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