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Bringing Mass Spec to the Masses - From niche tool to necessity: the history of MS in the pharmaceutical industry Bringing Mass Spec to the Masses - From niche tool to necessity: the history of MS in the pharmaceutical industry
This article on the history and impact of mass spectrometry in the pharmaceutical industry is the first in a new series for Pharmaceutical Formulation & Quality, the premier source of news and information for pharmaceutical and biopharmaceutical industry professionals. [October 14, 2009]
Mass Spectral Libraries - Reproducibility in EI, API and Tandem Mass Spectrometry Mass Spectral Libraries - Reproducibility in EI, API and Tandem Mass Spectrometry
A number of publications have recently appeared in which attempts have been made to determine the reproducibility of tandem mass spectra libraries. For several decades libraries of EI spectra have been used successfully for compound identification, especially from GC-MS data, while, in contrast, many difficulties seem to be present in trying to achieve the same success for tandem mass spectrometry data. This short essay attempts to answer the question of why this difference should occur, what is it about EI spectra which are so reproducible over a wide variety of instruments, laboratories and over long periods of time and what methods have been tried to improve the success rate of the latter. [May 15, 2009]
Capillary GC Coupled with Mass Spectrometry (GC-MS) Capillary GC Coupled with Mass Spectrometry (GC-MS) [registered users only]
This tutorial is brought to you by Chromedia - a new on-line community for today's practical chromatographers. The tutorial covers the basics of mass spectrometric instrumentation, ionization techniques, principles of mass analyzers and mass spectra interpretation. [September 1, 2008]
Watson & Sparkman, Introduction to Mass Spectrometry: Supplementary Files Watson & Sparkman, Introduction to Mass Spectrometry: Supplementary Files
This page gives access to the Instructor's Support files, PowerPoint files containing high quality versions of all the figures and EXE animation files. [December 10, 2007]
Fundamental LC-MS Fundamental LC-MS [registered users only]
This free tutorial, brought to you by earl provides an introduction to the various LC-MS techniques. [September 11, 2007]
Mass Spectrometry: A Primer Mass Spectrometry: A Primer
O. David Sparkman - Adjunct Professor of Chemistry at the University of the Pacific - presents a primer on the theory and technology of mass spectrometry. [September 2, 2007]
Proteomics Primer Proteomics Primer
In this primer, Dr Amna Butt presents a 'back to basics' overview of proteomics and the important role played by mass spectrometry. [September 1, 2007]
Atmospheric Pressure Ionisation of Small Molecules Atmospheric Pressure Ionisation of Small Molecules
Since the early 1980s many different and ingenious attempts have been made to achieve reliable and sensitive ionisation at atmospheric pressure in order to provide mass spectrometric data from molecules which were too involatile and thermally unstable to be submitted to probe or GC analysis. This article will address the application of ESI, ApCI and, to a lesser extent, the recent development of photoionisation (APPI), and direct desorption spray ionisation methods, as they are applied to small molecule analysis and is an attempt to show how many different classes of molecule can be examined by these techniques. [November 27, 2006]
Mass Spectrometry Bibliography for Beginners Mass Spectrometry Bibliography for Beginners
This listing is intended for absolute beginners in using mass spectrometry. [November 26, 2006]
Mass Spectrometry Glossary of Terms Mass Spectrometry Glossary of Terms
A list of some of the most common terms and abbreviations used in mass spectrometry, compiled by Professor Anthony Mallet, University of Greenwich, London [September 28, 2005]
A Primer on LC/NMR/MS A Primer on LC/NMR/MS
In this primer, Steve Down provides a detailed look at how these analytical techniques have been coupled together to provide an extremely powerful bioanalytical tool. [September 28, 2005]
Proteomics Glossary Proteomics Glossary
A glossary of common terms in proteomics, reproduced with the permission of Cambridge Healthtech Institute [September 28, 2005]
What is Molecular Mass? What is Molecular Mass?
Molecular Weights of Ions and Molecules: Different definitions used by chemists, biochemists and mass spectrometrists. [September 28, 2005]
Proteomics: the move to mixtures Proteomics: the move to mixtures
This special feature paper, published in the Journal of Mass Spectrometry, highlights the benefits of using LC/MS/MS methods in proteome analysis in favour of the traditional 2DE/MS technique. [September 28, 2005]
Periodic Puzzle Applet Periodic Puzzle Applet
Try out this periodic table applet...it's more than just your average periodic table jigsaw puzzle! [September 21, 2005]
Elemental composition from accurate <I>m</I>/<I>z</I> determinations Elemental composition from accurate m/z determinations
Professor Tony Mallet of the University of Greenwich presents an essay on elemental compositions from 'accurate mass' determinations. [September 20, 2005]