.... http://www.spectroscopyNOW.com/coi/cda/landing.cda?type=Feature&chId=5 http://www.spectroscopyNOW.com/coi/cma/download.cma?imageType=RssLogo&contentType=Feature&siteId=1&chId=5 http://www.spectroscopynow.com/ http://www.spectroscopyNOW.com/coi/cda/detail.cda?chId=5&id=23148&type=Feature&page=1 The first NMR spectroscopy study of the copper site in an important blue metalloprotein, azurin, has been undertaken. Copper mediates many biochemical redox reactions and azurin plays an important role in catalysing electron transfer in cellular reactions. http://www.spectroscopyNOW.com/coi/cda/detail.cda?chId=5&id=23050&type=Feature&page=1 Magnetic resonance spectroscopy, the molecular cousin of MRI could be used to pinpoint the exact location of prostate cancers and to determine the aggressiveness of a tumour, according to research published in the Science Translational Medicine. The approach could help guide treatment. http://www.spectroscopyNOW.com/coi/cda/detail.cda?chId=5&id=22993&type=Feature&page=1 Two-dimensional <font size=1><sup>1</sup></font>H <I>J</I>-resolved (JRES) NMR spectroscopy is widely used in metabolomics studies of plants and animals. This review provides a basic introduction to the technique and then discusses and recommends key strategies for both spectral acquisition and processing. Strategies for implementing JRES spectroscopy into the metabolomics toolbox are then considered, including for metabolic fingerprinting, metabolite identification and metabolite quantification. http://www.spectroscopyNOW.com/coi/cda/detail.cda?chId=5&id=22949&type=Feature&page=1 A novel NMR technique has measured the largest distance between two atomic nuclei using NMR, demonstrating that tritium magic angle spinning NMR could be a promising tool for structural applications in the biological and material sciences. http://www.spectroscopyNOW.com/coi/cda/detail.cda?chId=5&id=22866&type=Feature&page=1 An international team has used NMR spectroscopy to study neglected regions of key cell-surface proteins. They have found that these regions undergo minute conformational changes in response to drugs, a finding that could ultimately prove useful in the design of new drugs for a range of diseases. http://www.spectroscopyNOW.com/coi/cda/detail.cda?chId=5&id=22871&type=Feature&page=1 An NMR chemical shift prediction system was developed that enables high throughput automatic grading of NMR Spectra. This system used atom connectivity, stereochemistry, and experimental solvent. The accuracy of the system was demonstrated to estimate proton chemical shifts with an average error of +/-0.16 ppm. http://www.spectroscopyNOW.com/coi/cda/detail.cda?chId=5&id=22752&type=Feature&page=1 The first demonstration of how metabolic analysis using NMR spectroscopy to analyse a urine sample for diagnosis of community-acquired pneumonia has been undertaken. The simple diagnostic could be useful as the incidence of community-acquired pneumonia rises across the globe. http://www.spectroscopyNOW.com/coi/cda/detail.cda?chId=5&id=22731&type=Feature&page=1 Solid-state NMR spectroscopy can analyse intact bone and could lead to atomic-level explorations of how disease and aging affect bone. It could show, for instance, how age-related water loss leads to structural changes. http://www.spectroscopyNOW.com/coi/cda/detail.cda?chId=5&id=22619&type=Feature&page=1 An enigmatic component of human semen, SEVI, semen-derived enhancer of virus infection, boosts infectivity of the human immunodeficiency virus (HIV) which causes AIDS. Since its discovery in 2007, researchers have been hoping to learn more about its structure with the aim of inhibiting its infection-promoting activity; NMR spectroscopy has now produced new clues. http://www.spectroscopyNOW.com/coi/cda/detail.cda?chId=5&id=22562&type=Feature&page=1 An international team has developed NMR methodology that allows them to measure Residual Dipolar Couplings in small molecules and so determine their absolute configuration where conventional techniques fail. http://www.spectroscopyNOW.com/coi/cda/detail.cda?chId=5&id=22516&type=Feature&page=1 The origins, history, and present status of the controversy surrounding a quantum description of the NMR signal as being due to radio waves are traced. http://www.spectroscopyNOW.com/coi/cda/detail.cda?chId=5&id=22456&type=Feature&page=1 Anticancer drugs for treating ovarian and colon cancer could use rare metals as weapons in the battle against these diseases. The presence of unusual metal centres in organometallic compounds presents a novel affront to tumour cells that may even beat cancer cells that have evolved resistance to conventional drugs. http://www.spectroscopyNOW.com/coi/cda/detail.cda?chId=5&id=22377&type=Feature&page=1 NMR spectroscopy has helped to show that microscopic marine microbes, phytoplankton, are the solution to a ten-year-old mystery about the source of an essential nutrient in the oceans, the phosphonates found in organic phosphorus. http://www.spectroscopyNOW.com/coi/cda/detail.cda?chId=5&id=22278&type=Feature&page=1 Researchers in Germany are working on an unprecedented high-temperature host-guest super molecule, visualised with NMR spectroscopy. The system might be used to study molecules trapped inside the capsule for hydrophobic and confinement effects. http://www.spectroscopyNOW.com/coi/cda/detail.cda?chId=5&id=22208&type=Feature&page=1 Four research papers, two of which were published in the journal Science, this week, and two submitted to the physics preprint archive, suggest that a long-sought icon of fundamental physics has finally been discovered - the magnetic monopole. This fundamental research could have enormous potential in materials research, nanotechnology, and eventually instrumentation. http://www.spectroscopyNOW.com/coi/cda/detail.cda?chId=5&id=22220&type=Feature&page=1 A linear correlation method is proposed for accurate assignments of the 13C{1H} NMR spectra of major fatty acid components in apricot kernel, avocado pear, grapeseed, macadamia nut, mango kernel and marula vegetable oils. This approach, under carefully defined conditions and concentrations, is useful for crowded regions of the NMR spectrum where significant peak overlap occurs. http://www.spectroscopyNOW.com/coi/cda/detail.cda?chId=5&id=22159&type=Feature&page=1 NMR spectroscopy has revealed that a chemical compound found in unpasteurised food can be present at unusually high levels in the red blood cells of pregnant women. The compound, ergothioneine, could be used as a biomarker for the potentially fatal condition, pre-eclampsia, which can cause severely raised blood pressure during pregnancy. http://www.spectroscopyNOW.com/coi/cda/detail.cda?chId=5&id=22100&type=Feature&page=1 NMR spectroscopy has been used in structural studies and a novel synthesis of a compound, cyclopamine, which is found in corn lilies and causes lambs born of ewes that eat the lilies to be born with a single eye in the middle of their foreheads. The compound might one day redeem itself as a human anticancer drug. http://www.spectroscopyNOW.com/coi/cda/detail.cda?chId=5&id=22110&type=Feature&page=1 In the course of implementing various water suppression schemes into the standard CPMG pulse program and evaluating their T<font size=1><sub>2</sub></font> measurement accuracy, it was discovered that the addition of a spin echo train improves the performance of common water suppression pulse programs, such as WATERGATE or Excitation Sculpting. In favorable cases, lines that are masked by the solvent peak can be recovered. http://www.spectroscopyNOW.com/coi/cda/detail.cda?chId=5&id=22018&type=Feature&page=1 An Italian and German research team has used NMR spectroscopy to fingerprint a person's metabolic phenotype. Their work shows that while the range of metabolic products and their concentrations varies significantly from person to person they are relatively stable over time for each individual.