Combined brain imaging using oxygen-17 NMR

Skip to Navigation

Blog Post

  • Published: Aug 5, 2013
  • Author: Steve Down
  • Channels: NMR Knowledge Base

View comments on this post

17O NMR spectroscopy enables the simultaneous measurement of cerebral blood flow and metabolic rate of oxygen in small animals, factors which normally require separate experiments to measure. The trick to combining the two procedures lies in the use of 17O2 as a tracer for inhalation and measuring the H217O that is produced.

This technique was described for the first time in Magnetic Resonance in Medicine when it was demonstrated on rats. The labelled water molecules can be tracked as a perfusion tracer and their decay rate can be used to determine cerebral blood flow, allowing the non-invasive measurement of both factors within a few minutes. The technique could also be expanded to include measurement of the oxygen extraction fraction which is a third measure of the balance between oxygen supply and metabolism.

The same method will be suitable for studying other organs and will facilitate the study of healthy and diseased brains in vivo.

Comments

There are currently no comments on this post.

Comment Form

You have to log in to comment on this post.

Log in using the form at the top of the page or register here.

Social Links

Share This Links

Bookmark and Share

Microsites

Suppliers Selection
Societies Selection

Banner Ad

Click here to see
all job opportunities

Most Viewed

Copyright Information

Interested in separation science? Visit our sister site separationsNOW.com

Copyright © 2017 John Wiley & Sons, Inc. All Rights Reserved