Application of 19 F quantitative NMR to pharmaceutical analysis

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EarlyView Article

  • Published: Mar 8, 2018
  • Author: Allison O. Mattes, David Russell, Evgeny Tishchenko, Yanzhou Liu, Robert H. Cichewicz, Sarah J. Robinson
  • Journal: Concepts in Magnetic Resonance Part A


The presence of fluorine in an active pharmaceutical ingredient (API) can impart important pharmacological attributes with regards to metabolism, stability, and selectivity. As such, nearly one‐third of newly approved small molecule drugs contain at least one fluorine atom. 19F is 100% naturally abundant lending to virtually unimpeded detection of fluorine‐containing molecules, even in complex mixtures. Despite these promising characteristics, the thorough evaluation of a method for 19F qNMR (quantitative NMR) has been lacking. Herein we present experimental methodology and optimized parameters for uniform quantitative sampling of fluorine‐containing drugs and we compare results obtained using both gravimetric and absolute concentration methods for data reduction.

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