Raman spectroscopy as a novel method in placental research: Recognizing the pattern of placental hypoxia

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EarlyView Article

  • Published: Sep 15, 2017
  • Author: Natalia Schlabritz‐Loutsevitch, Kushal Gandhi, Fatimah Soydemir, Paul Brownbill, Raghvendra Sengar, Gary Ventolini, Paul Bruillard, Luke Gosink
  • Journal: Journal of Raman Spectroscopy

Abstract

Raman spectroscopy (RS) is a nonelastic photon scattering technique. We evaluated whether a specific RS pattern exists in fetal venous perfusates obtained at 30‐ to 60‐min intervals from the ex vivo human dual placental perfusion model under hypoxic (n = 6) and normoxic (n = 5) conditions. A stratified principle component and a linear support vector machine analyses showed that the separation between 2 conditions was readily feasible at 60–120 min of perfusion; after this, any apparent differences were most likely the result of artifact overfitting. This report is the first attempt to identify the RS fingerprint associated with placental hypoxia.

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