Development of a new in‐vial standard gas system for calibrating solid‐phase microextraction in high‐throughput and on‐site applications

In this work, an innovative, reproducible, and reusable standard generator vial is presented. The standard generator vial consists of vacuum‐pump oil doped with McReynolds probes (benzene, 2‐pentanone, pyridine, nitropropane, 1‐pentanol, and n‐octane) mixed with a polystyrene‐divinylbenzene resin without functional groups. The evaluation of this vial was fully automated on a multifiber exchanger system and the extraction/desorption cycle, together with the programmed GC–qMS analysis, did not exceed 13 min. The results showed that after 160 extraction/injections cycles of the vial the relative SDs were smaller than 4% for all the standards. A randomized block design was used to evaluate the inter and intravial repeatability, and at 95% level of confidence nonstatistical differences among vials were found. Because of its compacted granular appearance this vial is easy to transport, and it is an ideal calibration standard for bench and field instruments and devices.