Application of ionic‐liquid‐magnetized stirring bar liquid‐phase microextraction coupled with HPLC for the determination of naphthoquinones in Zicao

Skip to Navigation

EarlyView Article

  • Published: Dec 21, 2017
  • Author: Lianyue Guan, Qiang Luo, Jiayuan Shi, Wei Yu
  • Journal: Journal of Separation Science


In this study, a green, rapid, and simple method, ionic‐liquid‐magnetized stirring bar liquid‐phase microextraction was developed for the determination of naphthoquinones, including shikonin and β,β′‐dimethylacrylshikonin, in Zicao. This method permits active magnetic stirring, extraction, and pre‐enrichment in a single device simultaneously, so the extract is conveniently collected. The analytes were extracted from the sample to ionic liquid‐magnetized stirring bar, then the analyte‐adsorbed magnetized stirring bar can be readily isolated from the sample solution by a magnet. The key experimental parameters were investigated and optimized, including the type and volume of ionic liquid, extraction time, salt concentration, stirring speed, and pH. The recoveries were in the range of 89.47–102.38%, and good reproducibilities were obtained with relative standard deviation below 5.36%. Compared with the conventional extraction methods, the proposed method is quicker and more effective.

Social Links

Share This Links

Bookmark and Share


Suppliers Selection
Societies Selection

Banner Ad

Click here to see
all job opportunities

Most Viewed

Copyright Information

Interested in separation science? Visit our sister site

Copyright © 2018 John Wiley & Sons, Inc. All Rights Reserved