Journal Highlight: Tandem mass spectrometry for characterization of covalent adducts of DNA with anticancer therapeutics

Skip to Navigation

Ezine

  • Published: Aug 12, 2013
  • Author: spectroscopyNOW
  • Channels: Base Peak
thumbnail image: Journal Highlight: Tandem mass spectrometry for characterization of covalent adducts of DNA with anticancer therapeutics
This review focuses on the array of tandem mass spectrometric strategies developed and applied for characterization of covalent adducts formed between DNA and anticancer ligands.


Tandem mass spectrometry for characterization of covalent adducts of DNA with anticancer therapeutics

Mass Spectrometry Reviews, 2013, 32, 247-266
Catherine Silvestri, Jennifer S. Brodbelt

Abstract: The chemotherapeutic activities of many anticancer and antibacterial drugs arise from their interactions with nucleic acid substrates. Some of these ligands interact with DNA in a way that causes conformational changes or damage to the nucleic acid targets, ultimately altering recognition by key DNA-specific enzymes, interfering with DNA transcription or prohibiting replication, and terminating cell growth and proliferation. The design and synthesis of ligands that bind to nucleic acids remains a dynamic field in medicinal chemistry and pharmaceutical research. The quest for more selective and efficacious DNA-interactive anticancer chemotherapeutics has likewise catalyzed the need for sensitive analytical methods that can provide structural information about the nature of the resulting DNA adducts and provide insight into the mechanistic pathways of the DNA/drug interactions and the impact on the cellular processes in biological systems. This review focuses on the array of tandem mass spectrometric strategies developed and applied for characterization of covalent adducts formed between DNA and anticancer ligands.

  • This paper is free to view for all users registered on spectroscopyNOW.com until the end of September 2013.
    After this time, you can purchase it using Pay-Per-View on Wiley Online Library.

Social Links

Share This Links

Bookmark and Share

Microsites

Suppliers Selection
Societies Selection

Banner Ad

Click here to see
all job opportunities

Most Viewed

Copyright Information

Interested in separation science? Visit our sister site separationsNOW.com

Copyright © 2017 John Wiley & Sons, Inc. All Rights Reserved