Journal Highlight: Metals and electrolytes in sclerotic hippocampi in patients with drug-resistant mesial temporal lobe epilepsy

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  • Published: Jun 2, 2014
  • Author: spectroscopyNOW
  • Channels: Atomic
thumbnail image: Journal Highlight: Metals and electrolytes in sclerotic hippocampi in patients with drug-resistant mesial temporal lobe epilepsy
The hippocampi of patients with drug-resistant mesial temporal lobe epilepsy and hippocampal sclerosis who underwent anterior temporal lobe resection and amygdalohippocampectomy were analysed using ICP-OES.


Metals and electrolytes in sclerotic hippocampi in patients with drug-resistant mesial temporal lobe epilepsy

Epilepsia, 2014, 55, e34-e37
Aleksandar J. Ristić, Dragoslav Sokić, Vladimir Baščarević, Snežana Spasić, Nikola Vojvodić, Slobodan Savić, Savo Raičević, Maša Kovačević, Danijela Savić and Ivan Spasojević

Abstract: An altered metal and electrolyte profile has been implicated in the pathologic mechanisms of chronic epilepsy; however, no study has comprehensively measured hippocampal concentrations of these elements in patients with mesial temporal lobe epilepsy and hippocampal sclerosis (mTLE-HS). We therefore analyzed hippocampi of 24 patients with drug-resistant mTLE-HS (mean age 35.6 ± 9.4 years) who underwent anterior temporal lobe resection and amygdalohippocampectomy and 17 hippocampi obtained by autopsy from 13 controls (mean age 40.5 ± 12.9 years), using inductively coupled plasma optical emission spectrometry (ICP-OES). Epileptic hippocampi showed significantly lower concentrations (μg/g of tissue) of copper (HS: 2.34 ± 0.12; control [C]: 3.57 ± 0.33; p < 0.001), manganese (HS: 0.205 ± 0.030; C: 0.409 ± 0.064; p = 0.004), and potassium (HS: 2,001 ± 59; C: 2,322 ± 61; p < 0.001), and increased sodium levels (HS: 1,131 ± 22; C: 1,040 ± 25; p = 0.010). Zinc, iron, calcium, and magnesium levels did not differ in HS and controls. In summary, copper and manganese levels are deficient, whereas iron level is unchanged in hippocampi from patients with mTLE-HS. Our results provide a basis for understanding the potential involvement of different metals and electrolytes in the pathology of HS.

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