Journal Highlight: Non-invasive measurements of energy expenditure and respiratory quotient by respiratory mass spectrometry in children on extracorporeal membrane oxygenation - A pilot study

Skip to Navigation

Ezine

  • Published: Oct 5, 2015
  • Author: spectroscopyNOW
  • Channels: Base Peak
thumbnail image: Journal Highlight: Non-invasive measurements of energy expenditure and respiratory quotient by respiratory mass spectrometry in children on extracorporeal membrane oxygenation - A pilot study
Respiratory mass spectrometry has been adapted to continuously measure O2 consumption and CO2 production in the gas exchange across the extracorporeal membrane oxygenator and the ventilator for paediatric patients.

Non-invasive measurements of energy expenditure and respiratory quotient by respiratory mass spectrometry in children on extracorporeal membrane oxygenation - A pilot study

Artificial Organs, 2015, 39, 815-819
Xiaohui Li, Xiaoyang Yu, Andriy Cheypesh and Jia Li

Abstract: Extracorporeal membrane oxygenation (ECMO) provides temporary life-saving support for pediatric patients with severe cardiac failure, but causes metabolic disturbances and altered nutritional requirements. However, few studies have addressed the optimal energy supply to meet the demand of these children, largely due to technical difficulties with their invasive nature. We have adapted respiratory mass spectrometry to continuously measure O2 consumption and CO2 production in the gas exchange across the ECMO oxygenator, as well as that across the ventilator. This study aimed to assess energy expenditure (EE) and respiratory quotient (RQ) in children on ECMO. Five children (aged 0.3 to 36 months, median 20) were studied between Day 1 and Day 6 on ECMO. EE and RQ were measured in sequential fashion at the child's native lungs and ECMO oxygenator using respiratory mass spectrometry. Measurements were collected at 4-h intervals, with the means in 24 h representing the values of each day. Each child's caloric and protein intakes were recorded for each day. Between ECMO Days 1 and 6, there was a small but significant increase in EE from 40 to 46 kcal/kg/day (P = 0.03). In comparison, the caloric intake significantly increased by twice as much as EE from 30 to 61 kcal/kg/day (P = 0.017). As a result, RQ significantly increased from 0.6 to 1.0 (P < 0.0001). Protein intake significantly increased during ECMO Days 1 to 6 from 0.5 to 1.5 g/kg/day (P = 0.04). Respiratory mass spectrometry is feasible to provide a unique and safe technique to measure EE and RQ in patients on ECMO. Without this knowledge, inadequate feeding may occur. Further studies are warranted in a larger patient population to provide better information to guide clinical practice in this special group of critically ill children.

  • This paper is free to view for all users registered on spectroscopyNOW.com until the end of November 2015.
    After this time, you can purchase it using Pay-Per-View on Wiley Online Library.

Follow us on Twitter!

Social Links

Share This Links

Bookmark and Share

Microsites

Suppliers Selection
Societies Selection

Banner Ad

Click here to see
all job opportunities

Most Viewed

Copyright Information

Interested in separation science? Visit our sister site separationsNOW.com

Copyright © 2017 John Wiley & Sons, Inc. All Rights Reserved