Journal Highlight: Development of a library search-based screening system for 3,4-methylenedioxymethamphetamine in ecstasy tablets using a portable near-infrared spectrometer

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  • Published: Oct 3, 2016
  • Author: spectroscopyNOW
  • Channels: Infrared Spectroscopy
thumbnail image: Journal Highlight: Development of a library search-based screening system for 3,4-methylenedioxymethamphetamine in ecstasy tablets using a portable near-infrared spectrometer
A library search-based screening system has been developed for MDMA in ecstasy tablets using a portable NIR spectrometer, giving no false positive results.

Development of a library search-based screening system for 3,4-methylenedioxymethamphetamine in ecstasy tablets using a portable near-infrared spectrometer

Journal of Forensic Sciences, 2016, 61, 1208-1214
Kenji Tsujikawa, Tadashi Yamamuro, Kenji Kuwayama, Tatsuyuki Kanamori, Yuko T. Iwata, Kazuna Miyamoto, Fumiyo Kasuya and Hiroyuki Inoue

Abstract: This is the first report on development of a library search-based screening system for 3,4-methylenedioxymethamphetamine (MDMA) in ecstasy tablets using a portable near-infrared (NIR) spectrometer. The spectrum library consisted of spectra originating from standard substances as well as mixtures of MDMA hydrochloride (MDMA-HCl) and diluents. The raw NIR spectra were mathematically pretreated, and then, a library search was performed using correlation coefficient. To enhance the discrimination ability, the wavelength used for the library search was limited. Mixtures of MDMA-HCl and diluents were used to decide criteria to judge MDMA-positive or MDMA-negative. Confiscated MDMA tablets and medicinal tablets were used for performance check of the criteria. Twenty-two of 27 MDMA tablets were truly judged as MDMA-positive. Five false-negative results may be caused by compounds not included in the library. No false-positive results were obtained for medicinal tablets. This system will be a useful tool for on-site screening of MDMA tablets.

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