Journal Highlight: Omics-based approaches to understand mechanosensitive endothelial biology and atherosclerosis

Skip to Navigation

Ezine

  • Published: Oct 24, 2016
  • Author: spectroscopyNOW
  • Channels: Proteomics
thumbnail image: Journal Highlight: Omics-based approaches to understand mechanosensitive endothelial biology and atherosclerosis
Omics approaches to the study of atherosclerosis are reviewed to show how they can reveal the pathophysiology and identify novel molecular diagnostics and therapeutic targets to prevent or treat the disease.

Omics-based approaches to understand mechanosensitive endothelial biology and atherosclerosis

Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 2016, 8, 378-401
Rachel D. Simmons, Sandeep Kumar, Salim Raid Thabet, Sanjoli Sur and Hanjoong Jo

Abstract: Atherosclerosis is a multifactorial disease that preferentially occurs in arterial regions exposed to d-flow can be used to indicate disturbed flow or disturbed blood flow. The mechanisms by which d-flow induces atherosclerosis involve changes in the transcriptome, methylome, proteome, and metabolome of multiple vascular cells, especially endothelial cells. Initially, we begin with the pathogenesis of atherosclerosis and the changes that occur at multiple levels owing to d-flow, especially in the endothelium. Also, there are a variety of strategies used for the global profiling of the genome, transcriptome, miRNA-ome, DNA methylome, and metabolome that are important to define the biological and pathophysiological mechanisms of endothelial dysfunction and atherosclerosis. Finally, systems biology can be used to integrate these ‘omics’ datasets, especially those that derive data based on a single animal model, in order to better understand the pathophysiology of atherosclerosis development in a holistic manner and how this integrative approach could be used to identify novel molecular diagnostics and therapeutic targets to prevent or treat atherosclerosis.

  • This paper is free to view for all users registered on spectroscopyNOW.com until the end of December 2016.
    After this time, you can purchase it using Pay-Per-View on Wiley Online Library.

Follow us on Twitter!

Social Links

Share This Links

Bookmark and Share

Microsites

Suppliers Selection
Societies Selection

Banner Ad

Click here to see
all job opportunities

Most Viewed

Copyright Information

Interested in separation science? Visit our sister site separationsNOW.com

Copyright © 2017 John Wiley & Sons, Inc. All Rights Reserved