Journal Highlight: The new face of isotopic NMR at natural abundance

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  • Published: Mar 6, 2017
  • Author: spectroscopyNOW
  • Channels: NMR Knowledge Base
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The main concepts, definitions, applications and improvements of NMR-based isotope analysis at natural abundance have been reviewed.

The new face of isotopic NMR at natural abundance

Magnetic Resonance in Chemistry, 2017, 55, 77-90
Tangi Jézéquel, Valentin Joubert, Patrick Giraudeau, Gérald S. Remaud and Serge Akoka

Abstract: The most widely used method for isotope analysis at natural abundance is isotope ratio monitoring by Mass Spectrometry (irm-MS) which provides bulk isotopic composition in 2H, 13C, 15N, 18O or 34S. However, in the 1980s, the direct access to Site-specific Natural Isotope Fractionation by Nuclear Magnetic Resonance (SNIF-NMRTM) was immediately recognized as a powerful technique to authenticate the origin of natural or synthetic products. The initial – and still most popular – application consisted in detecting the chaptalization of wines by irm-2H NMR. The approach has been extended to a wide range of methodologies over the last decade, paving the way to a wide range of applications, not only in the field of authentication but also to study metabolism. In particular, the emerging irm-13C NMR approach delivers direct access to position-specific 13C isotope content at natural abundance. After highlighting the application scope of irm-NMR (2H and 13C), this article describes the major improvements which made possible to reach the required accuracy of 1‰ (0.1%) in irm-13C NMR. The last part of the manuscript summarizes the different steps to perform isotope analysis as a function of the sample properties (concentration, peak overlap) and the kind of targeted isotopic information (authentication, affiliation).

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