Journal Highlight: Sample preparation methods for MALDI-MS profiling of bacteria

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  • Published: Jun 20, 2011
  • Channels: Sample Preparation
thumbnail image: Journal Highlight: Sample preparation methods for MALDI-MS profiling of bacteria

Sample preparation methods for MALDI-MS profiling of bacteria

Mass Spectrometry Reviews 2011, 30, 417-434
Ondrej Sedo, Ivo Sedlacek, Zbynek Zdrahal

Abstract: Direct matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) bacterial cell or lysate analysis appears to meet all the criteria required for a rapid and reliable analytical microorganism identification and taxonomical classification tool. Few-minute analytical procedure providing information extending up to sub-species level underlines the potential of the MALDI-MS profiling in comparison with other methods employed in the field. However, the quality of MALDI-MS profiles and consequently the performance of the method are influenced by numerous factors, which involve particular steps of the sample preparation procedure. This review is aimed at advances in development and optimization of the MALDI-MS profiling methodology. Approaches improving the quality of the MALDI-MS profiles and universal feasibility of the method are discussed.

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 Advances in the development and optimization of MALDI-MS profiling methodology for bacterial cell or lysate analysis have been reviewed. Methods for improving the quality of the profiles and the universal feasibility of the method were also discussed

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