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Comprehensive Characterization of Proteins using Novel Orbitrap Tribrid MS

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  • Published: Nov 6, 2013
  • Author: Shannon Eliuk and Rosa VinerThermo
  • Categories: Proteomics & Genomics / Base Peak / Proteomics
thumbnail image: <font color=red>Now available on-demand</font><br/>Webinar:<br/>Comprehensive Characterization of Proteins using Novel Orbitrap Tribrid MS

Comprehensive Characterization of Proteins using a
Novel Orbitrap Tribrid Mass Spectrometer:
The Game Changer for PTM Analysis

Broadcast on December 3, 2013
This webinar is now available on-demand.
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Phosphorylation and glycosylation are two common posttranslational modifications (PTMs) of proteins that perform critical roles in the regulation of many cellular processes including cell cycle, signal transduction pathways, recognition, gene expression and cellular immunity.

Mass spectrometry is a powerful tool for the detection and identification of PTMs. Comprehensive characterization of proteins include localization of the modification site, characterization of structures and quantification of the various modified forms to fully understand the effect on protein function. Electron Transfer Dissociation (ETD) is a fragmentation technique that has been used enthusiastically for peptide identification, localization of labile post-translational modifications (PTMs) and sequence polymorphisms.

This webinar demonstrates the advantages of using a novel Orbitrap mass spectrometer for qualitative and quantitative PTM analysis. The novel arrangement of the three mass analyzers plus advances in software not only increases the rate of high quality ETD spectra, but also the ease of routinely obtaining high quality ETD data.

Enhanced peptide ID will be discussed as well as PTM identification and localization for both phosphorylation and glycosylation.

Key Learning Objectives:

  • Understanding unique capabilities of Orbitrap Fusion MS and ETD for PTM analysis
  • Complete quantitative and qualitative PTM workflows

Who Should Attend?

  • Protein Chemists
  • Biologists
  • Proteomics Researchers 

Your Presenters 

Shannon Eliuk

Shannon Eliuk
New Technology Development Specialist
Life Science Mass Spectrometry
Thermo Fisher Scientific

Rosa Viner

Rosa Viner
Proteomics Program Manager
Life Science Mass Spectrometry
Thermo Fisher Scientific

In association with:
Pittcon 2014

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