Waters new REIMS Research System with iKnife Technology Reduces Sampling Time to Seconds

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  • Published: Jun 1, 2015
  • Source: Waters Corporation
  • Channels: Proteomics & Genomics / HPLC / Proteomics / Base Peak
thumbnail image: Waters new REIMS Research System with iKnife Technology Reduces Sampling Time to Seconds

System Delivers Molecular Profiling in Seconds, Offering a Pioneering Solution for Research Laboratories

St Louis, MI. June 1, 2015.

Waters Corporation has introduced the Rapid Evaporative Ionization Mass Spectrometry™ (REIMS™) Research System with iKnife™ Sampling, combining direct-from-sample ionization with high performance time-of-flight mass spectrometry and powerful, intuitive analytics. The system eliminates the need for sample preparation and chromatographic separation, providing food, microbiology and tissue researchers with near-instantaneous data acquisition.

Using Waters® REIMS Research System with iKnife Sampling, researchers can quickly and easily differentiate samples from one another and confidently identify the differentiating features, allowing greater insight into the chemical and biological systems under investigation. In REIMS, direct, rapid heating of the samples leads to the formation of vapor that is rich in sample-specific chemical information. The vapor is taken directly into the mass spectrometer (Xevo® G2-XS QTof or SYNAPT® G2-Si HDMS) where the molecules are analyzed by time-of-flight mass spectrometry.

“The new system will deliver REIMS technology into the hands of many more scientists working in important areas such as research into food fraud and adulteration, where we anticipate its impact could be game-changing”, said Brian Smith, Vice President of Mass Spectrometry Operations at Waters.

As the global demand increases, food is increasingly making longer and more complicated journeys from farms to tables. As a result, the opportunities for the introduction and spread of contamination increase. In addition, food fraud is gaining interest as an emerging risk given the increasingly global and complex nature of supply chains. According to the World Customs Organization, food fraud (including the deliberate mislabeling of food and blending lower and higher quality raw materials in processed foods) is estimated to cost the world economy $49 billion (USD) annually. It is clear that new technologies are needed to combat these challenges.

The REIMS Research System also features Progenesis QI® software, which offers an intuitive, workflow-based approach to process large data sets using powerful multivariate statistical methods. This quickly highlights differences within and between samples, allowing them to be grouped in an objective and unbiased way. Key molecular components can be identified and characterized, and results can be exported to take advantage of other informatics platforms, including molecular pathway analysis tools.


In 2014, Waters acquired REIMS technology from MediMass Ltd. (Budapest), the developer of the iKnife - a device in the conceptual stages of development that could potentially be used for real-time diagnostics in surgery.

At that time Waters began to explore the potential of REIMS to bring ambient ionization sampling into applications—chief among them, food safety. Less than a year later, Waters is announcing the availability of the REIMS Research System for non-clinical applications.

Waters is committed to exploring the viability of this application in accordance with all applicable regulatory requirements. To date, no regulatory approvals have been sought for this device.

About Waters Corporation

For more than 50 years, Waters Corporation has created business advantages for laboratory-dependent organizations by delivering practical and sustainable innovation to enable significant advancements in such areas as healthcare delivery, environmental management, food safety, and water quality, consumer products and high-value added chemicals worldwide. Pioneering a connected portfolio of separations science, laboratory information management, mass spectrometry and thermal analysis, Waters technology breakthroughs and laboratory solutions provide an enduring platform for customer success. With revenue of $1.99 billion in 2014, Waters is driving scientific discovery and operational excellence for customers worldwide.

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