Magritek reviews the current use of benchtop NMR in real-time monitoring and optimization of chemical reactions

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  • Published: Aug 18, 2015
  • Source: Magritek
  • Channels: NMR Knowledge Base / MRI Spectroscopy
thumbnail image: Magritek reviews the current use of benchtop NMR in real-time monitoring and optimization of chemical reactions

Aachen, Germany. August 18, 2015.

Magritek, a leading provider of compact NMR and MRI instruments, announce the posting of a new educational video on following chemical reactions in real time on the bench using the Magritek Spinsolve NMR spectrometer. Given by CEO Dr Andrew Coy, this lecture is one of a series of webinars organised by software provider Mestrelab on the growth in benchtop NMR solutions.

Mestrelab Research produces a software program called Mnova which is widely used by organic chemists to analyse NMR spectra. Magritek customers often use MNova to carry out their NMR data processing and analysis. Mestrelab organised a series of webinars on benchtop NMR and invited Magritek CEO, Dr Andrew Coy to describe the growth of applications using benchtop NMR to monitor reactions in real time.

The Spinsolve Benchtop NMR Spectrometer is robust enough to be deployed outside the controlled environment of an NMR laboratory, and has the performance to provide quick, reliable and useful chemical information. While traditional superconducting NMR means bringing the sample to the spectrometer, the benefit of a benchtop NMR Spectrometer is that it can be deployed next to the reaction and monitor its progress in real time. In this presentation video, Dr Coy introduces the Spinsolve Benchtop NMR Spectrometer and discusses some of the issues to consider in NMR reaction monitoring. Results are presented from a number of different applications and research groups, and highlight some of the future developments and trends that are likely to impact this field.

In this review, the focus is on reaction monitoring where a system maybe set up in a routine fume hood as would be found in most organic and synthetic chemistry laboratories. The ability to quickly track a reaction, i.e. monitoring the decay of reactants while simultaneously following the reaction products, helps chemists determine reaction parameters when scaling up to the production line. Systems are now in use worldwide with many publications now appearing in the peer-reviewed literature illustrating the acceptance of benchtop NMR analysis. One particularly exciting development is that of Professor Lee Cronin´s group from the University of Glasgow1 where he has been studying imine synthesis. By applying closed loop control he is able to self-optimise the experiment protocol to maximise yield through iterative routines.

With over a dozen applications examples described in some detail, the presentation is an excellent introduction to those wishing to use NMR in their research or teaching activities. To view the video, just click here.

To obtain full details of the Spinsolve family of benchtop NMR spectrometers and the full range of analytical products from Magritek, visit, For details of Mestrelab and their Mnova product, go to


  1. A self optimizing synthetic organic reactor system using real-time in-line NMR spectroscopy”: DOI: 10.1039/c4sc03075c. (This is an open access publication).

About Magritek

Magritek provides complete NMR and MRI solutions and applications for Chemical, Pharmaceutical, Oil and Gas, Food and Construction Industries as well as components and subsystems suitable for Research Laboratories and Academic Education. Magritek has offices in Aachen, Germany, San Diego, USA, and Wellington, New Zealand and a global network of distributors and agents to support customers. The initial NMR technology and IP used in Magritek products grew out of decades of world-class research by Ampere prize winner Professor Bernhard Bluemich's group at RWTH Aachen University, and Gunther Laukien prize winner Paul Callaghan's team at Massey University and Victoria University of Wellington. For details on Magritek and all its products and solutions, please visit

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