Counterfeit Viagra and Cialis by ATR-FTIR

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  • Published: Feb 28, 2013
  • Author: Steve Down
  • Channels: Base Peak / Chemometrics & Informatics / MRI Spectroscopy / Infrared Spectroscopy / NMR Knowledge Base / Atomic / UV/Vis Spectroscopy / X-ray Spectrometry / Proteomics / Raman

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Counterfeit samples of Viagra and Cialis can be distinguished from authentic samples by ATR-FTIR spectroscopy, say Brazilian researchers, who also pinpointed a single mixture as a common source for tablets of both types. Rafael Ortiz and colleagues from the Brazilian Federal Police and the Federal University of Rio Grande do Sul compared the spectra of genuine Viagra and Cialis, containing the active ingredients sildenafil citrate and tadalafil, respectively, with those of seizures, as described in Forensic Science International.

The region of interest in the spectra was at 1800-525 cm–1, which represents the fingerprint region in which the differences were evident. By applying principal components analysis and similarity matching to the peaks in this range, genuine tablets were easily discriminated from counterfeit ones. In addition, tablets from individual seizures were distinguished from those in other seizures. The process also revealed that some batches of illicit Viagra and Cialis were manufactured from the same mixture of ingredients, which contained sildenafil as the only active ingredient.

Fast and reliable results were obtained within 30 seconds, providing a quick and simple surveillance tool for forensic and drug testing labs.

Comments

1. At 05:07 on Apr 9, 2014, Hardik Patel wrote:

good content

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