Journal Highlight: Sodium MRI of glioma in animal models at ultrahigh magnetic fields

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  • Published: Mar 21, 2016
  • Author: spectroscopyNOW
  • Channels: MRI Spectroscopy
thumbnail image: Journal Highlight: Sodium MRI of glioma in animal models at ultrahigh magnetic fields
This review is devoted to the unique features of sodium MRI in tumor animal models, mainly in glioma, and the ability of the technique to monitor tumor response to therapy is evaluated.

Sodium MRI of glioma in animal models at ultrahigh magnetic fields

NMR in Biomedicine, 2016, 29, 175-186
Victor D. Schepkin

Abstract: High magnetic fields expand our capability to use sodium MRI for biomedical applications. The central goal of this review is devoted to the unique features of sodium MRI in tumor animal models, mainly in glioma, performed at 9.4 and 21.1 T. The ability of sodium MRI to monitor tumor response to therapy was evaluated. It is noteworthy that sodium MRI can detect glioma response to chemotherapy earlier than diffusion MRI. Especially attractive is the ability of sodium MRI to predict tumor therapeutic resistance before therapy. The non-invasive prediction of tumor chemo-resistance by sodium MRI presents a potential to individualize strategies for cancer treatment. Specifics of sodium MRI and technical aspects of imaging are also presented.

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