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Assessment of metabolic changes in the striatum of a rat model of parkinsonism: an in vivo 1H MRS study

Date: Feb 24, 2009

Author:

Degeneration of the dopaminergic neurons of the substantia nigra pars compacta in Parkinson's disease induces an abnormal activation of the glutamatergic neurotransmission system within the basal ganglia network and related structures. The aim of this study was to use proton MRS to show metabolic changes in the striatum of 6-hydroxydopamine-lesioned rats, a rodent animal model of Parkinson's disease.

Read More thumbnail image: Assessment of metabolic changes in the striatum of a rat model of parkinsonism an in vivo 1H MRS study

Nano MRI

Date: Feb 1, 2009

Author: David Bradley

Researchers at IBM working with a team at Stanford University have demonstrated MRI with a volume resolution 100 million times better than possible conventional systems. The technology could herald single-cell MRI.

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Recent advances in breast MRI and MRS

Date: Jan 27, 2009

Author:

Breast MRI is an area of intense research and is fast becoming an important tool for the diagnosis of breast cancer. This review, taken from the current Breast MRI Special Issue of NMR in Biomedicine covers recent advances in breast MRI, MRS, and image post-processing and analysis.

Read More thumbnail image: Recent advances in breast MRI and MRS

Crime and punishment

Date: Jan 1, 2009

Author: David Bradley

A truly interdisciplinary collaboration between biology, law and neuroscience at Vanderbilt University has used functional magnetic resonance imaging fMRI to watch how the brain changes when a person thinks about crime and punishment.

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Monitoring response to chemotherapy of non-Hodgkin's lymphoma xenografts by T2-weighted and diffusion-weighted MRI

Date: Dec 18, 2008

Author:

An effective method for in vivo detection of early therapeutic response of patients with non-Hodgkin's lymphoma would enable personalized clinical management of cancer therapy and facilitate the design of optimal treatment regimens. This study evaluates the feasibility of T2-weighted MRI and diffusion-weighted MRI for in vivo detection of response of human diffuse large B-cell lymphoma xenografts in severe combined immunodeficient mice to chemotherapy.

Read More thumbnail image: Monitoring response to chemotherapy of non-Hodgkins lymphoma xenografts by T2-weighted and diffusion-weighted MRI

Minestrone and magnetic resonance

Date: Dec 1, 2008

Author: David Bradley

Researchers in the US and France may have overturned decades of theory in magnetic resonance studies by spotting a discrepancy in the way nuclear spins behave. Their new mathematical model of the process improves our understanding of atomic behaviour and could lead to better NMR spectra, sharper magnetic resonance images, and perhaps one day a fully portable MRI machine.

Read More thumbnail image: Minestrone and magnetic resonance

Voting and image

Date: Nov 1, 2008

Author: David Bradley

Functional magnetic resonance imaging studies reveal that voters are persuaded more by the negative aspects of a politician's looks than by the positive features. The findings apply specifically if the voter was previously unaware of the politician. Ahead of the US elections, voters there should read on but let their political conscience guide their voting decision.

Read More thumbnail image: Voting and image

Prognostic MRI biomarkers of treatment efficacy for retinopathy

Date: Oct 22, 2008

Author:

There is a pressing need for retina-specific imaging biomarkers that robustly measure early changes in physiology, are linked to the histopathology responsible for vision loss, and, importantly, predict treatment efficacy. In this paper, the authors conclude that functional MRI biomarkers are most promising for prognostic evaluation of treatment efficacy earlier in the course of retinopathy than is currently possible.

Read More thumbnail image: Prognostic MRI biomarkers of treatment efficacy for retinopathy

Anticipating excitation

Date: Oct 1, 2008

Author: David Bradley

Functional magnetic resonance imaging (fMRI) has revealed a reason why the excitement of unwrapping presents dwindles as our brains get older and more jaded. According to a new study, a biochemical pathway is responsible for mellowing our expectations.

Read More thumbnail image: Anticipating excitation

Identification and characterisation of childhood cerebellar tumours by in vivo proton MRS

Date: Sep 22, 2008

Author:

1H MRS has great potential for the clinical investigation of childhood brain tumours, but the low incidence in, and difficulties of performing trials on, children have hampered progress in this area.

Read More thumbnail image: Identification and characterisation of childhood cerebellar tumours by in vivo proton MRS
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