SCIEX launches next-generation CESI-MS platform

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  • Published: Nov 11, 2015
  • Author: Jon Evans
  • Source: SCIEX
  • Suppliers: AB SCIEX
  • Channels: Electrophoresis / Base Peak

SCIEX has launched the CESI 8000 Plus, their next generation capillary electrophoresis-electrospray ionization-mass spectrometry (CESI-MS) platform. This new platform further advances CESI-MS, enabling multiple experiments to be generated from as little as 5μL of starting material. Combining this capability with the multi-segment injection methodology allows 10 experiments to be processed in the time it would normally take to process one, with less than 1μL consumed.

This system is ideal for experiments where samples are limited, including microdialysates, needle biopsies, FFPE archives, rare circulating tumor cells or where samples are highly toxic. In addition, the innovation of neutral capillary surfaces further reduces system flow to less than 10nL/min. The CESI 8000 Plus delivers higher resolution separations, improved ionization efficiency and reduced ion suppression. Optional laser-induced fluorescence, diode-array and selectable wavelength UV detector modules are available, enabling off-line method development capability on this platform.

The CESI 8000 Plus allows the separation of intact protein isoforms followed by mass spectrometry for researchers who need to understand the critical characteristics of biotherapeutics in development. CESI-MS provides a liquid-phase ion mobility separation, which now makes it possible to resolve closely related proteoforms, glycoforms, phosphorylated species and other post-translational modifications (PTMs) on proteins.

For academics, the OptiMS neutral capillary cartridge allows researchers to map and separate complex proteomes using either protein digest or intact protein strategies. For the first time, enzymes, protein-protein and receptor-ligand complexes can now be investigated with high resolution separation in a native state, allowing their structure/function relationships to be studied with mass spectrometry. Metabolomics researchers can take advantage of a single platform for analysis of both negatively- and positively-charged metabolites, allowing the automated analysis of these analytes without having to change columns or reagents.

“When SCIEX introduced CESI-MS several years ago, we set a new benchmark for the needs of biopharma scientists, and now the CESI 8000 Plus represents another breakthrough for scientists working in other applications,” said John Plohetski, global vice president, separations at SCIEX. “Combined with the unique separation selectivity and enhanced sensitivity, our customers are utilizing the CESI 8000 Plus to get more information from precious samples that may only be available in limited quantity, and they are identifying proteins and protein modifications never before reported.”


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