SCIEX Launches New X500B QTOF Mass Spectrometry System for Standardised Biotherapeutic Characterisation

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  • Published: Jan 25, 2017
  • Source: SCIEX
  • Channels: Base Peak
thumbnail image: SCIEX Launches New X500B QTOF Mass Spectrometry System for Standardised Biotherapeutic Characterisation

Newest X500 Mass Spec System is the first true benchtop, accurate mass system for simple, robust and rapid biologics characterisation during drug development

Framingham, MA. January 25, 2017.

SCIEX, a global leader in life science analytical technologies, today announced its latest solution in the X-Series Quadrupole Time of Flight (QTOF) mass spectrometry (MS) platform. The newest X-Series model, the X500B QTOF System, brings simplicity, high performance and robustness for biotherapeutic analyses to one of the most compact MS system footprints on the market. The new user-friendly SCIEX OS Software interface and powerful BioPharmaViewTM 2.0 processing software comprise an unmatched integrated LC-MS solution for mass spec experts, or novices, performing standard biotherapeutic characterisation.

The X500R QTOF System emerged in 2015 as the first LC-MS solution designed specifically for routine food, environmental and forensic testing. It introduced an entirely new industrial design, fully loaded with easy-to-use software, methods and libraries, custom-designed for targeted customer applications. The X500R QTOF has since won awards and achieved accolades from industry-leading laboratories and key opinion leaders.

The X500B QTOF System was specifically developed to deliver ease-of-use for high resolution standardised workflows for biotherapeutic developers, who are required to fully characterise biologic products in large numbers during the development process. Many MS-based workflows require users to be MS system experts who must perform complicated data processing and manual calculations. The workflows can be complex to set up and involve intensive and sometimes confusing software. The X500B QTOF offers the robust and streamlined, quality instrumentation that SCIEX is known for, with the intuitive SCIEX OS user interface for simplified workflow setup.

To simplify complex data processing, the X500B QTOF System comes with BioPharmaView Software 2.0, enabling scientists to generate better information, faster. BioPharmaView Mass Spec Software also offers the ability to interpret SWATH® 2.0 data independent acquisition on the X500B QTOF System. SWATH acquisition allows for comprehensive peptide mapping data to be acquired in a single injection, with high-resolution MS and MSMS data for every peptide in the sample. This strategy results in the ability to detect important low-abundance peptides and post-translational modifications that may be missed with other approaches. With the X500B QTOF System, all users can achieve expert level results in their biotherapeutic characterisation workflows.

“Mass spec users have been asking for systems that are purpose built for their application, and SCIEX has listened,” said Farzana Azam, Senior Director, Pharmaceutical/CRO Business at SCIEX. “The introduction of the X500B System brings a new level of simplicity, robustness and integration to simplify the complex world of biologics characterisation. The combination of this innovative, true benchtop QTOF system, and software such as SCIEX OS and unique SWATH Acquisition, creates the complete easy-to-use and streamlined solution for standard biologic analyses.”

SCIEX will be presenting the X500B at the CASSS WCBP 21st Symposium, January 24–26, 2017. Learn more about the X500B from SCIEX at and


SCIEX helps to improve the world we live in by enabling scientists and laboratory analysts to find answers to the complex analytical challenges they face. The company's global leadership and world-class service and support in the capillary electrophoresis and liquid chromatography-mass spectrometry industry have made it a trusted partner to thousands of the scientists and lab analysts worldwide who are focused on basic research, drug discovery and development, food and environmental testing, forensics and clinical research. With over 40 years of proven innovation, SCIEX excels by listening to and understanding the ever-evolving needs of its customers to develop reliable, sensitive and intuitive solutions that continue to redefine what is achievable in routine and complex analysis. For more information, please visit

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