MALDI MS with High Resolution / Accurate Mass powered with OrbitrapTM Technology

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  • Date: May 17, 2011 - 15:00 - 16:00 (local time)
  • Categories: Base Peak
thumbnail image: MALDI MS with High Resolution / Accurate Mass powered with Orbitrap<sup>TM</sup> Technology

Latest webinar
from Thermo Scientific

Thermo Scientific

MALDI MS with High Resolution / Accurate Mass
Powered with OrbitrapTM Technology

This webinar was broadcast on May 17, 2011
and is now available to view on-demand

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High Resolution / Accurate Mass Performance of Matrix-Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometry on Orbitrap-based instrumentation is presented discussing the instrumental design with its MALDI intermediate pressure collisional cooling interface.

Performance of the instrumentation is shown with regard to mass resolution, mass accuracy, sensitivity and dynamic range. Experimental setup for Automatic Gain Control (AGC) in MALDI mode is provided.

Application examples deriving from LC MALDI (proteomics) towards MALDI MS Imaging of small molecules analyzed directly from tissue will be shown.

Who should attend?

  • Labs that already apply MALDI technique to TOF instrumentation
  • Labs that serve as an MS facility in a larger organisation (university, research lab)
  • Labs that require high mass resolution and accurate mass for their MALDI application from small molecules towards peptide applications
  • Research Labs that focus on metabolism research directly from tissue
  • Lab Managers and Lab Directors

Your speaker...

Dr. Kerstin StrupatKerstin Strupat, MALDI-MS Product Manager at Thermo Fisher Scientific, received her Diploma and PhD degree in Physics from the University of Muenster, Germany, in 1995. Both, diploma and PhD theses were performed in the group of Prof. Franz Hillenkamp and Michael Karas in the Institute for Medical Physics and Biophysics of the University of Muenster. Kerstin was then a research scientist at the Max Planck Institute (MPI) for Biochemistry in Munich, Germany, followed by stay in the Institute de Spectrométrie de Masse Bio-Organique (LSMBO), Strasbourg, France. Her research topic during the MPI stay was to study how proteins can be mass analyzed, if bound directly to solid surfaces (e.g. bound to electroblotting membranes after a transfer from a 2D PAGE), using IR MALDI-MS. Her MALDI-MS related studies on the analysis of non-covalently bound protein-protein interactions allowed her to get financial support from the German Research Council (DFG) to approve a 13-month stay in France to study non-covalent complexes by ESI-MS. Kerstin has been involved with mass spectrometric ionization techniques, ESI and MALDI since then. She is author or coauthor of more than 35 peer-reviewed papers and contributed to seven book chapters or review articles.

Kerstin joint Thermo Fisher Scientific in 2003 and became a product specialist for FTMS-based instrumentation; this has been FT ICR technology in the beginning, and since 2005 this is in addition Orbitrap-based instrumentation. As of the beginning of 2007, Kerstin started to help implementing MALDI-related aspects in Orbitrap-based instrumentation, software- and hardware-wise. Since end of 2010, Kerstin has been driving the development of the MALDI portfolio out of Bremen, Germany.

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