Advances in the forensic analysis of synthetic drugs with LC/MS/MS

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  • Date: Oct 6, 2011 - 15:00 - 16:00 (local time)
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Forensic Toxicology Mass Spec

Advances in the Forensic Analysis
of Synthetic Drugs with LC/MS/MS

 

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Overview

According to the changing nature of synthetic drugs, forensic toxicologists are looking for new screening tool to identify new cannabinoid products as well as their metabolites and ultimately to propose new confirmation methods to quantify the drug level in human fluid such as urine.

This webinar will focus on recent advances in the forensic analysis of synthetic drugs using LC/MS/MS.

Jeff Moran from the Arkansas Department of Health, USA, will present his LC/MS/MS development responding to forensic toxicology concerns associated with K2 Spice products as an emerging area of forensic testing.

Then, Patrice Tremblay from Phytronix Technologies, Canada, will present a fast and quantitative screening method for the JWH-018 and JWH-073 metabolites in urine combine the ultra-fast LDTD ion source with high resolution LC/MS/MS system.


Your Speakers

Jeff Moran Patrice Tremblay
Dr. Jeff Moran
Branch Chief, Environmental Chemistry,
Arkansas Department of Health, USA

Dr. Patrice Tremblay
Scientific Coordinator, R&D Applications,
Phytronix Technologies, Canada

Dr. Jeff Moran: Biography

Dr. Jeffery H. Moran graduated Suma Cum Laude in 1996 with an American Chemical Society approved B.Sc. degree from Arkansas Tech University. While an undergraduate, Dr. Moran's passion for toxicology and analytical chemistry became evident. His first peer reviewed paper reporting a new assay to detect cell death was published in 1996. In 1997, Dr. Moran continued his toxicological training through graduate studies at the University of Arkansas for Medical Sciences. During this time, Dr. Moran studied mechanisms of cellular death and fatty acid metabolism. He graduated in 2001 with a Ph.D.

After graduate training, Dr. Moran worked as a toxicological consultant for the Center for Toxicology and Environmental Health, LLC, where he specialized in emergency response, industrial hygiene, and public health. In this role, Dr. Moran worked with local, state, national, and tribal regulatory authorities to determine evacuation orders and to develop workplace / community exposure guidelines and assessment plans. These assessments required a strong understanding of combustion and chemical reaction byproduct chemistry as well as understanding downstream environmental and public health consequences. In 2005, Dr. Moran accepted his current position as Branch Chief for Environmental Chemistry at the Arkansas Department of Health. His regulatory and research laboratories specialize in EPA, FDA, and CDC methods which routinely measure low levels of chemicals present in environmental, drinking water, food, and clinical specimens. To this end, he and his staff maintain several analytical platforms including GC-MS, ICP-MS, and LC-MS, as well as several automated sample preparation stations. Dr. Moran also has active academic appointments at the University of Arkansas for Medical Sciences in the Colleges of Medicine and Public Health. His independent research focuses on drug metabolism and analytical pharmacology.
Patrice Tremblay: Biography

Patrice Tremblay completed an undergraduate degree in chemistry at the University of Sherbrooke. He obtained a Master's degree in 2001 in chemistry at the University of Québec in Montréal. This work was a collaborative study with the Institut de Recherche Robert-Sauvé en Santé et Sécurité du Travail, a scientific research organization for occupational health and safety. During his M.Sc., Patrice Tremblay evaluated and validated four international methods (Canada, USA, UK and Sweden) for analyzed isocyanates in air.

Patrice then joined the research team of Martine Savard, at the Institut de la Recherche Scientifique, working in collaboration with M. Real Paquin's team at Laval University. He completed a Doctorate in water sciences, specializing in geochemistry and instrumental chemistry. He developed the first in-line permeation apparatus coupled to an in-line isotopic ratio mass spectrometer for carbon isotopic ratio measurement. His work was performed in collaboration with the company Phytronix Technologies, based in Québec. It was during his Ph.D. degree that Patrice Tremblay was introduced to the high throughput Laser Diode Thermal Desorption (LDTD) ion source, which was developed by Phytronix Technologies in 2006. To extend his knowledge in mass spectrometry, Patrice undertook a post-doctoral position at Phytronix Technologies in 2006-2007, where he developed many applications using the LDTD ion source.

He joined Phytronix Technologies in 2007 as the principle application chemist and he is now the Scientific Coordinator, R&D Applications. Since then, Patrice has co-authored many published papers, posters and presentations about the LDTD. He is also the co-supervisor of a Ph.D. candidate, who works for Mme Satinder H. Bra and M. Rajeshwar D. Tiagi at the INSR-ETE. In human toxicology, Patrice has worked with some US companies on drug testing in human urine samples using the LDTD, which he is now further developing with his coworkers.

 

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