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Protein Carbonylation: Principles, Analysis, and Biological Implications

Date: Jul 7, 2017

Author: Joaquim Ros

Protein carbonylation has attracted the interest of a great number of laboratories since the pioneering studies at the Earl Stadtman’s lab at NIH started in early 1980s. Since then, detecting protein carbonyls in oxidative stress situations became a highly efficient tool to uncover biomarkers of oxidative damage in normal and altered cell physiology. In this book, research groups from several areas of interest have contributed to update the knowledge regarding detection, analyses and identification...

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Solid State Properties of Pharmaceutical Materials

Date: Jul 7, 2017

Author: Stephen Byrn, George Zografi, Xiaoming (Sean) Chen

Presents a detailed discussion of important solid-state properties, methods, and applications of solid-state analysis Illustrates the various phases or forms that solids can assume and discussesvarious issues related to the relative stability of solid forms and tendencies to undergo transformation Covers key methods of solid state analysis including X-ray powder diffraction, thermal analysis, microscopy, spectroscopy, and solid state NMR Reviews critical physical attributes of pharmaceutical materials,...

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Oral Bioavailability Assessment: Basics and Strategies for Drug Discovery and Development

Date: Jun 30, 2017

Author: Ayman F. El-Kattan, Mike S. Lee

Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development.•    Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability•    Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic...

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Forensic Science Education and Training

Date: Jun 9, 2017

Author: Anna Williams, John Paul Cassella, Peter D. Maskell

A comprehensive and innovative guide to teaching, learning and assessment in forensic science education and practitioner training Includes student exercises for mock crime scene and disaster scenarios Addresses innovative teaching methods including apps and e-gaming Discusses existing and proposed teaching methods

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MALDI-TOF and Tandem MS for Clinical Microbiology

Date: Jun 2, 2017

Author: Haroun N. Shah, Saheer E. Gharbia

This book highlights the triumph of MALDI-TOF mass spectrometry over the past decade and provides insight into new and expanding technologies through a comprehensive range of short chapters that enable the reader to gauge their current status and how they may progress over the next decade.  This book serves as a platform to consolidate current strengths of the technology and highlight new frontiers in tandem MS/MS that are likely to eventually supersede MALDI-TOF MS. Chapters discuss:Challenges of...

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Limits of Detection in Chemical Analysis

Date: May 12, 2017

Author: Edward Voigtman

Details methods for computing valid limits of detection. Clearly explains analytical detection limit theory, thereby mitigating incorrect detection limit concepts, methodologies and results Extensive use of computer simulations that are freely available to readers Curated short-list of important references for limits of detection Videos, screencasts, and animations are provided at an associated website, to enhance understanding Illustrated, with many detailed examples and cogent explanations

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Food Authentication: Management, Analysis and Regulation

Date: May 5, 2017

Author: Contantinos A. Georgiou, Georgios P. Danezis

The determination of food authenticity is a vital component of quality control. Its importance has been highlighted in recent years by high-profile cases in the global supply chain such as the European horsemeat scandal and the Chinese melamine scandal which led to six fatalities and the hospitalisation of thousands of infants. As well as being a safety concern, authenticity is also a quality criterion for food and food ingredients. Consumers and retailers demand that the products they purchase and sell...

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Mass Spectrometry and Stable Isotopes in Nutritional and Pediatric Research

Date: Mar 24, 2017

Author: Henk Schierbeek

A guide for scientists, pediatricians and students involved in metabolic studies in pediatric research Addresses the availability of modern analytical techniques and how to apply these techniques in metabolic studies Covers the whole range of available mass spectrometric techniques used for metabolic studies including Stable Isotope Methodology Presents the relevance of mass spectrometry and stable isotope methodology in pediatric research covering applications in Nutrition, Obesity, Metabolic Disorders,...

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Oral Formulation Roadmap from Early Drug Discovery to Development

Date: Mar 24, 2017

Author: Elizabeth Kwong

Detailing formulation approaches by stage of discovery to early development, this book gives a “playbook” of practical and efficient strategies to formulate drug candidates with the least chance of failing in clinical development. •    Comes from contributing authors with experience developing formulations on the frontlines of the pharmaceutical industry•    Focuses on pre (or non-) clinical and early stage development, the phases where most compounds are...

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Interpretation of MS-MS Mass Spectra of Drugs and Pesticides

Date: Mar 17, 2017

Author: Wilfried M. A. Niessen, Ricardo A. Correa C.

Provides comprehensive coverage of the interpretation of LC–MS–MS mass spectra of 1300 drugs and pesticides Provides a general discussion on the fragmentation of even-electron ions (protonated and deprotonated molecules) in both positive-ion and negative-ion modes   This is the reference book for the interpretation of MS–MS mass spectra of small organic molecules  Covers related therapeutic classes of compounds such as drugs for cardiovascular diseases, psychotropic compounds,...

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