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Journal Highlight: Optimization of extraction and analytical protocol for mass spectrometry‐based metabolomics analysis of hepatotoxicity

Date: Sep 10, 2018

Author: spectroscopyNOW

An optimised LC/MS‐based metabolomics protocol for extraction and analysis of endogenous metabolites from liver tissue during hepatotoxicity provides high reliability and reproducibility for polar and nonpolar metabolites.

Read More thumbnail image: Journal Highlight Optimization of extraction and analytical protocol for mass spectrometrybased metabolomics analysis of hepatotoxicity

Alternative cigarettes: Prison teabacco hybrids analysed

Date: Sep 1, 2018

Author: Steve Down

An analysis of teabacco, the substitute tobacco made from tea leaves and nicotine lozenges that is prepared and produced by prison inmates, has uncovered unhealthy levels of toxic metals in the smoke but fewer harmful organic compounds than from normal cigarettes.

Read More thumbnail image: Alternative cigarettes Prison teabacco hybrids analysed

Martian conundrum solved: Viking lander data reexamined for organics

Date: Aug 15, 2018

Author: Steve Down

The original GC/MS data sets from the Mars Viking landers in the 1970s have been reexamined to reveal the presence of Martian organic compounds, 40 years before they were detected by the Curiosity rover.

Read More thumbnail image: Martian conundrum solved Viking lander data reexamined for organics

Journal Highlight: Interrogation of spatial metabolome of Ginkgo biloba with high‐resolution MALDI and LDI mass spectrometry imaging

Date: Aug 6, 2018

Author: spectroscopyNOW

Mass spectrometry imaging has been used to interrogate the spatio‐chemical localization of metabolites across the ginkgo leaf using MALDI and LDI FTICR MS.

Read More thumbnail image: Journal Highlight Interrogation of spatial metabolome of Ginkgo biloba with highresolution MALDI and LDI mass spectrometry imaging

Illicit fentanyls: Paper spray mass spectrometry for testing in the field

Date: Aug 1, 2018

Author: Steve Down

Fentanyl-type drugs of abuse have been screened, identified and measured in urine by paper spray mass spectrometry in a procedure which could be developed into point-of-use testing for forensic and emergency personnel.

Read More thumbnail image: Illicit fentanyls Paper spray mass spectrometry for testing in the field

Journal Highlight: Investigation of variations in the human urine metabolome amongst European populations: An exploratory search for biomarkers of people at risk‐of‐poverty

Date: Jul 16, 2018

Author: spectroscopyNOW

The human urine metabolome has been examined for common biomarkers representing dietary deficiencies amongst European populations at risk of poverty and the relationship between these markers and nutritional deficiencies was discussed.

Read More thumbnail image: Journal Highlight Investigation of variations in the human urine metabolome amongst European populations An exploratory search for biomarkers of people at riskofpoverty

Homemade explosives: Inorganic oxidisers exposed

Date: Jul 15, 2018

Author: Steve Down

Atmospheric flow tube-mass spectrometry, which has been used to detect conventional explosives, has now been applied successfully to the detection of inorganic salts used as oxidisers in homemade explosives.

Read More thumbnail image: Homemade explosives Inorganic oxidisers exposed

Journal Highlight: The expanding role of mass spectrometry in the field of vaccine development

Date: Jul 9, 2018

Author: spectroscopyNOW

In this review, the role of mass spectrometry in vaccine development is presented, some of the ongoing efforts to develop vaccines for diseases with global unmet medical need are discussed and the regulatory challenges of implementing mass spectrometry techniques in a quality control laboratory setting are highlighted.

Read More thumbnail image: Journal Highlight The expanding role of mass spectrometry in the field of vaccine development

Salmonella in milk: Volatile organic compounds exposé

Date: Jul 1, 2018

Author: Steve Down

The presence of Salmonella in milk can be confirmed by the detection of specific volatile organic compounds generated by the action of endogenous enzymes on specially added substrates within five hours.

Read More thumbnail image: Salmonella in milk Volatile organic compounds expose

Biofluid identity: Forensic evidence

Date: Jun 15, 2018

Author: Steve Down

Human body fluids collected at crime scenes can be classified from their constituent proteins in a single mass spectrometric experiment that can be combined with DNA analysis for suspect identification.

Read More thumbnail image: Biofluid identity Forensic evidence
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