Monitoring liver metabolites to correct medical radiation malpractice

Skip to Navigation

Blog Post

  • Published: Apr 23, 2015
  • Author: Steve Down
  • Channels: Atomic / MRI Spectroscopy / Base Peak / Raman / Infrared Spectroscopy / X-ray Spectrometry / Chemometrics & Informatics / NMR Knowledge Base / Proteomics / UV/Vis Spectroscopy

View comments on this post

Radiation treatment is one of the key weapons against cancer but it is a dangerous practice because of the risk of damage to neighbouring healthy tissue. Evidence of clinical negligence or malpractice is not easy to come by but DNA damage and chromosome alteration are potential indicators.

Scientists in the Republic of Korea have investigated a new approach based on small metabolites rather than DNA and it would have the advantage that it could also indicate when the patient was exposed. It monitored the metabolites to see how their levels changed over time after radiation exposure, as explained in Bulletin of the Korean Chemical Society.

Using rats that were exposed to whole body X-ray irradiation of 6 Gy, the metabolites in the liver were analysed by NMR spectroscopy and compared using principal components analysis. From 32 metabolites that were identified certain subsets distinguished between animals that had been exposed or not exposed. More importantly, it was possible to discriminate between animals that had been subjected to 24 or 72 hours of exposure. So, the time of exposure can be extrapolated from the levels of the metabolites.

Some of the key discriminating compounds were glucose, glycine, ethanolamine and maltose which helped to earmark samples that had been irradiated 24 hours earlier. Others like aspartic acid, glutamine, succinic acid and lysine were signals for 72-hour exposure.

The research team hope that the work will eventually lead to a way of identifying patients at risk from radiation overexposure so that they can be treated appropriately.

Comments

There are currently no comments on this post.

Comment Form

You have to log in to comment on this post.

Log in using the form at the top of the page or register here.

Social Links

Share This Links

Bookmark and Share

Microsites

Suppliers Selection
Societies Selection

Banner Ad

Click here to see
all job opportunities

Copyright Information

Interested in separation science? Visit our sister site separationsNOW.com

Copyright © 2017 John Wiley & Sons, Inc. All Rights Reserved