Journal Highlight: T1 Nuclear magnetic relaxation dispersion of hyperpolarized sodium and cesium hydrogencarbonate-13C

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  • Published: Sep 4, 2017
  • Author: spectroscopyNOW
  • Channels: NMR Knowledge Base
thumbnail image: Journal Highlight: <em>T</em><sub>1</sub> Nuclear magnetic relaxation dispersion of hyperpolarized sodium and cesium hydrogencarbonate-<sup>13</sup>C

The T1 dispersion from low to clinical magnetic fields of different hyperpolarized hydrogencarbonate formulations previously proposed in the literature for in vivo pH measurements has been measured to aid pH mapping in tissue.

T1 Nuclear magnetic relaxation dispersion of hyperpolarized sodium and cesium hydrogencarbonate-13C

NMR in Biomedicine, 2017, 30, e3749 online
Francisco M. Martínez-Santiesteban, Thien Phuoc Dang, Heeseung Lim, Albert P. Chen and Timothy J. Scholl

Abstract: In vivo pH mapping in tissue using hyperpolarized hydrogencarbonate-13C has been proposed as a method to study tumor growth and treatment and other pathological conditions related to pH changes. The finite spin–lattice relaxation times (T1) of hyperpolarized media are a significant limiting factor for in vivo imaging. Relaxation times can be measured at standard magnetic fields (1.5 T, 3.0 T etc.), but no such data are available at low fields, where T1 values can be significantly shorter. This information is required to determine the potential loss of polarization as the agent is dispensed and transported from the polarizer to the MRI scanner. The purpose of this study is to measure T1 dispersion from low to clinical magnetic fields (0.4 mT to 3.0 T) of different hyperpolarized hydrogencarbonate formulations previously proposed in the literature for in vivo pH measurements. 13C–enriched cesium and sodium hydrogencarbonate preparations were hyperpolarized using dynamic nuclear polarization, and the T1 values of different samples were measured at different magnetic field strengths using a fast field-cycling relaxometer and a 3.0 T clinical MRI system. The effects of deuterium oxide as a dissolution medium for sodium hydrogencarbonate were also analyzed. This study finds that the cesium formulation has slightly shorter T1 values compared with the sodium preparation. However, the higher solubility of cesium hydrogencarbonate-13C means it can be polarized at greater concentration, using less trityl radical than sodium hydrogencarbonate-13C. This study also establishes that the preparation and handling of sodium hydrogencarbonate formulations in relation to cesium hydrogencarbonate is more difficult, due to the higher viscosity and lower achievable concentrations, and that deuterium oxide significantly increases the T1 of sodium hydrogencarbonate solutions. Finally, this work also investigates the influence of pH on the spin–lattice relaxation of cesium hydrogencarbonate-13C measured over a pH range of 7 to 9 at 0.47 T.

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