Journal Highlight: Insight into old and new pure shift nuclear magnetic resonance methods for enantiodiscrimination

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  • Published: Jul 2, 2018
  • Author: spectroscopyNOW
  • Channels: NMR Knowledge Base
thumbnail image: Journal Highlight: Insight into old and new pure shift nuclear magnetic resonance methods for enantiodiscrimination

Recent developments in the pure shift 1H NMR-based methods for enantiomer resolution and enantiodiscrimination have been reviewed and various pure shift methods used for enantiodiscrimination and measurement of enantiomeric excess discussed.

Insight into old and new pure shift nuclear magnetic resonance methods for enantiodiscrimination

Magnetic Resonance in Chemistry, 2018, online
Nilamoni Nath, Priyakshi Bordoloi, Bhaskar Barman, Bikash Baishya, Sachin R. Chaudhari

Abstract: Enantiodiscrimination and their quantification using nuclear magnetic resonance (NMR) spectroscopy has always been a subject of great interest. Proton is the nucleus of choice for enantiodiscrimination due to its high sensitivity and ubiquitous presence in nature. Despite its advantages, enantiodiscrimination suffers from extensive signal splitting by the proton‐proton scalar couplings, which give complex multiplets that spread over a frequency range of some tens of hertz. These multiplets often overlap, further complicating interpretation of the spectra and quantifications. In the present review, we discuss some of the recent developments in the pure shift 1H NMR based methods for enantiomer resolution and enantiodiscrimination. We also compare various pure shift methods used for enantiodiscrimination and measurement of enantiomeric excess, considering the fact that conventional 1H NMR fails to provide any detailed insight.

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