Journal Highlight: Extra‐large NMR spectroscopy (XLSY)

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  • Published: Oct 1, 2018
  • Author: spectroscopyNOW
  • Channels: NMR Knowledge Base
thumbnail image: Journal Highlight: Extra‐large NMR spectroscopy (XLSY)

eXtra Large NMR SpectroscopY (XLSY)  has been developed for experimental data collection, reconstruction and handling of very large NMR spectra by a combination of radial and non‐uniform sampling, a new processing algorithm and rigorous statistical validation.

Extra‐large NMR spectroscopy (XLSY)

Angewandte Chemie International Edition, 2018, online
Yulia Pustovalova, Maxim Mayzel, Vladislav Y Orekhov

Abstract: NMR studies of intrinsically disordered proteins and other complex biomolecular systems require spectra with the highest resolution and dimensionality. We present an efficient approach eXtra Large NMR SpectroscopY for experimental data collection, reconstruction, and handling of very large NMR spectra by a combination of the radial and non‐uniform sampling, a new processing algorithm, and rigorous statistical validation. We demonstrate the first high‐quality reconstruction of a full seven‐dimensional HNCOCACONH and two five‐dimensional HACACONH and HN(CA)CONH experiments for a representative intrinsically disordered protein α‐synuclein. XLSY will significantly enhance the NMR toolbox in challenging biomolecular studies.

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