Journal Highlight: Establishing the transitory existence of amorphous phases in crystallization pathways by the CLASSIC NMR technique

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  • Published: Nov 26, 2018
  • Author: spectroscopyNOW
  • Channels: NMR Knowledge Base
thumbnail image: Journal Highlight: Establishing the transitory existence of amorphous phases in crystallization pathways by the CLASSIC NMR technique

CLASSIC NMR (Combined Liquid‐ And Solid‐State In‐situ Crystallization NMR) has been used to reveal the transitory existence of amorphous phases during crystallization processes, demonstrating with DL‐menthol and L‐menthol.

Establishing the transitory existence of amorphous phases in crystallization pathways by the CLASSIC NMR technique

ChemPhysChem, 2018, online
Colan E. Hughes, P. Andrew Williams. Benson M. Kariuki, Kenneth D. M. Harris

Abstract: With the growing realization that crystallization processes may evolve through a sequence of different solid forms, including amorphous precursor phases, the development of suitable in‐situ experimental probes is essential for comprehensively mapping the time‐evolution of such processes. Here we demonstrate that the CLASSIC NMR (Combined Liquid‐ And Solid‐State In‐situ Crystallization NMR) strategy is a powerful technique for revealing the transitory existence of amorphous phases during crystallization processes, applying this technique to study crystallization of dl‐menthol and l‐menthol from their molten liquid phases. The CLASSIC NMR results provide direct insights into the conditions (including the specific time period) under which the molten liquid phase, transitory amorphous phases and final crystalline phases exist during these crystallization processes.

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