NMR for Drug Analysis: Assignment of Voriconazole

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  • Published: Nov 22, 2017
  • Source: JEOL
  • Channels: MRI Spectroscopy / NMR Knowledge Base

November 21, 2017. Peabody, MA.

A new JEOL technical note Application of HFX NMR to Facilitate the Complete Assignment of the Anti-fungal Agent Voriconazole describes the use of the new JEOL ROYAL HFX probe for Nuclear Magnetic Resonance (NMR) Spectroscopy in analysis of fluorine, found with an ever-increasing frequency in materials science and both legal and illicit drugs.

In this application note, results are presented to illustrate the simplification afforded by the routine application of triple-resonance NMR to clearly assign voriconazole, a molecule containing proton, carbon, and nitrogen molecules with many atoms exhibiting J-coupling to fluorine.

The JEOL ROYAL HFX NMR probe offers a new level of flexibility for NMR analysis of fluorinated compounds prevalent in wide variety of current products and many new products across a wide spectrum of industries. JEOL introduced the HFX probe earlier this year and has published several applications notes.

To see the full suite of NMR applications notes and product information, visit our webpage here: https://www.jeolusa.com/PRODUCTS/Nuclear-Magnetic-Resonance

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