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Gut feeling: NMR reveals PTSD link?

Date: May 1, 2016

Author: David Bradley

A nuclear magnetic resonance (NMR) spectroscopy by researchers at McMaster University in Ontario, Canada, hints at a possible link between the bacteria growing in your gut and neurological conditions such as post-traumatic stress disorder (PTSD), anxiety and perhaps even depression. 

Read More thumbnail image: Gut feeling NMR reveals PTSD link

All four corners: NMR and chiral carbons

Date: Apr 15, 2016

Author: David Bradley

A new approach to chiral synthesis that works under mild conditions has been validated with nuclear magnetic resonance (NMR) spectroscopy and other tools by scientists in Europe. Paolo Melchiorre of ICIQ, Institute Of Chemical Research Of Catalonia, and colleagues developed the technique using enantioselective iminium ion chemistry and photoredox catalysis to form quaternary carbon stereocentres with high enantioselectivity.

Read More thumbnail image: All four corners NMR and chiral carbons

Journal Highlight: Ultrafast magic-angle spinning: Benefits for the acquisition of ultrawide-line NMR spectra of heavy spin-1/2 nuclei

Date: Apr 4, 2016

Author: spectroscopyNOW

The benefits of the ultrafast magic-angle spinning approach for the acquisition of ultrawide-line NMR spectra have been demonstrated for tin oxide and a tin complex.

Read More thumbnail image: Journal Highlight Ultrafast magic-angle spinning Benefits for the acquisition of ultrawide-line NMR spectra of heavy spin-12 nuclei

Pain on the brain: NMR tracks analgesics

Date: Apr 1, 2016

Author: David Bradley

Nuclear magnetic resonance spectroscopy (NMR) can be used to measure brain metabolites following administration of painkillers and so provide a useful way to evaluate objectively the analgesic effect as well as to study the mode of action of old and new types of painkiller.

Read More thumbnail image: Pain on the brain NMR tracks analgesics

Zinc control: NMR untangles Alzheimer's

Date: Mar 15, 2016

Author: David Bradley

An important clue as to the underlying mechanism of Alzheimer's disease has been identified using nuclear magnetic resonance (NMR) spectroscopy by researchers from the Lomonosov Moscow State University scientists and their colleagues from the Institute of Molecular Biology, Russian Academy of Sciences and the King's College London. They report details in the journal Scientific Reports.

Read More thumbnail image: Zinc control NMR untangles Alzheimers

Journal Highlight: Rapid NMR assignments of proteins by using optimized combinatorial selective unlabeling

Date: Mar 8, 2016

Author: spectroscopyNOW

A new approach for rapid resonance assignments in proteins based on amino acid selective unlabeling can augment existing approaches and will be useful for identifying active-site residues involved in ligand binding, phosphorylation, or protein–protein interactions.

Read More thumbnail image: Journal Highlight Rapid NMR assignments of proteins by using optimized combinatorial selective unlabeling

Imaging Parkinson's protein: NMR and EPR

Date: Mar 1, 2016

Author: David Bradley

A combined approach using nuclear magnetic resonance (NMR) and electron paramagnetic resonance (EPR) spectroscopy reveals details of the changes that occur in the protein α-synuclein in Parkinson's disease.

Read More thumbnail image: Imaging Parkinsons protein NMR and EPR

NMR spots biosimilars: Filgrastim found

Date: Feb 15, 2016

Author: David Bradley

Protein NMR spectroscopy can be used to demonstrate the high similarity of the three dimensional structure between various product sources according to research published in the journal Nature Biotechnology.

Read More thumbnail image: NMR spots biosimilars Filgrastim found

Journal Highlight: A community resource of experimental data for NMR / X-ray crystal structure pairs

Date: Feb 8, 2016

Author: spectroscopyNOW

An online NMR / X-ray Structure Pair Data Repository has been developed to provide experimental structures for at least one representative of each of hundreds of targeted protein domain families.

Read More thumbnail image: Journal Highlight A community resource of experimental data for NMR  X-ray crystal structure pairs

Journal Highlight: NMR logging to estimate hydraulic conductivity in unconsolidated aquifers

Date: Feb 1, 2016

Author: spectroscopyNOW

The application of NMR logging in unconsolidated aquifers suggests that a new set of constants can be defined to give high-resolution, cost-effective estimates of the estimate hydraulic conductivity.

Read More thumbnail image: Journal Highlight NMR logging to estimate hydraulic conductivity in unconsolidated aquifers
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