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FAT10 to MAD2, do you copy? NMR clues to inflammatory cancer

Date: Mar 1, 2015

Author: David Bradley

The interaction between two proteins, FAT10 and MAD2, leads to cancers associated with inflammation, including liver (hepatocellular carcinoma) and colorectal cancers. NMR spectroscopy reveals new clues regarding the structure of FAT10 and might lead to innovative ways to disrupt this unique interaction and perhaps inhibit cancer.

Read More thumbnail image: FAT10 to MAD2 do you copy NMR clues to inflammatory cancer

Flu shot: NMR spectroscopy helps with model building

Date: Feb 15, 2015

Author: David Bradley

The combination of experimental data from nuclear magnetic resonance spectroscopy, X-ray crystallography,  cryoelectron microscopy and lipidomics has allowed researchers to build the first complete model of the outer envelope of an influenza A virion.

Read More thumbnail image: Flu shot NMR spectroscopy helps with model building

Journal Highlight: Nuclear magnetic resonance structure elucidation of peptide b2 ions

Date: Feb 1, 2015

Author: spectroscopyNOW

A strategy has been introduced to elucidate MS fragment ion structures using NMR spectroscopy for the first time, illustrated by the peptide b2 fragment ion.

Read More thumbnail image: Journal Highlight Nuclear magnetic resonance structure elucidation of peptide b2 ions

Functionalised nanocarbons: Chrome-plated NMR spectroscopy

Date: Feb 1, 2015

Author:

Proton NMR (nuclear magnetic resonance) spectroscopy, high-resolution mass spectrometry and X-ray crystallography have been used to probe chromium-centred cycloparaphenylene organometallic rings. The results could allow chemists to define ways to readily functionalize nanocarbons, according to research published in the Journal of the American Chemical Society.

Read More thumbnail image: Functionalised nanocarbons Chrome-plated NMR spectroscopy

Full of beans: NMR spectroscopy confirms coffee

Date: Jan 15, 2015

Author:

An international team from Colombia and Germany has demonstrated how to use NMR spectroscopy to identify adulteration or contamination of coffee beans based on country of origin, a useful tool in the fight against food fraud in a high-value market.

Read More thumbnail image: Full of beans NMR spectroscopy confirms coffee

Other side of the sheets: NMR battles bedbugs

Date: Jan 8, 2015

Author: David Bradley

Nuclear magnetic resonance (NMR) spectroscopy has outstripped gas-chromatography mass spectrometry in the search for an important pheromone of the increasingly common pest, the bedbug (Cimex lectularius).

Read More thumbnail image: Other side of the sheets NMR battles bedbugs

Journal Highlight: Examination of amber and related materials by NMR spectroscopy

Date: Jan 2, 2015

Author: spectroscopyNOW

The solid-state 13C and solution 1H NMR spectra of fossilized resins (ambers) has generated five groupings of materials based on spectral characteristics.

Read More thumbnail image: Journal Highlight Examination of amber and related materials by NMR spectroscopy

NMR spectroscopy rides in: Detects horse fat

Date: Dec 15, 2014

Author: David Bradley

The presence of horsemeat in adulterated meat products can now be revealed quickly and easily using nuclear magnetic resonance (NMR) spectroscopy to test the fat profile of the food without the need for complication and long-winded genetic analysis.

Read More thumbnail image: NMR spectroscopy rides in Detects horse fat

Journal Highlight: On the tuning of high-resolution NMR probes

Date: Dec 1, 2014

Author: spectroscopyNOW

Three optimum conditions for the tuning of NMR probes are compared: the conventional tuning optimum, the spin noise tuning optimum and the newly introduced frequency shift tuning optimum.

Read More thumbnail image: Journal Highlight On the tuning of high-resolution NMR probes

Equine ordure: NMR reveals fungal antibiotic

Date: Dec 1, 2014

Author: David Bradley

NMR spectroscopy reveals the structure of an antibiotic protein, copsin, from a surprising source: the grey shag fungus that grows on horse dung. The antibiotic has the same ultiamte effect on bacteria as small molecule compounds but offers an entirely different biochemistry that might be exploited in drugs to defeat antibiotic resistance.

Read More thumbnail image: Equine ordure NMR reveals fungal antibiotic
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