NMR Knowledge Base / Ezine
Absolute NMR for cancer compound
Date: Nov 15, 2009
Author: David Bradley
An international team has developed NMR methodology that allows them to measure Residual Dipolar Couplings in small molecules and so determine their absolute configuration where conventional techniques fail.
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The origins and present status of the radio wave controversy in NMR
Date: Nov 5, 2009
Author:
The origins, history, and present status of the controversy surrounding a quantum description of the NMR signal as being due to radio waves are traced.
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Cancer transition
Date: Nov 1, 2009
Author: David Bradley
Anticancer drugs for treating ovarian and colon cancer could use rare metals as weapons in the battle against these diseases. The presence of unusual metal centres in organometallic compounds presents a novel affront to tumour cells that may even beat cancer cells that have evolved resistance to conventional drugs.
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Mysterious marine microbe metabolism
Date: Oct 15, 2009
Author: David Bradley
NMR spectroscopy has helped to show that microscopic marine microbes, phytoplankton, are the solution to a ten-year-old mystery about the source of an essential nutrient in the oceans, the phosphonates found in organic phosphorus.
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Putting the squeeze on molecular guests
Date: Oct 1, 2009
Author: David Bradley
Researchers in Germany are working on an unprecedented high-temperature host-guest super molecule, visualised with NMR spectroscopy. The system might be used to study molecules trapped inside the capsule for hydrophobic and confinement effects.
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Monopoles apart
Date: Sep 15, 2009
Author: David Bradley
Four research papers, two of which were published in the journal Science, this week, and two submitted to the physics preprint archive, suggest that a long-sought icon of fundamental physics has finally been discovered - the magnetic monopole. This fundamental research could have enormous potential in materials research, nanotechnology, and eventually instrumentation.
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A novel approach to the rapid assignment of 13C NMR spectra of major components of vegetable oils such as avocado, mango kernel and macadamia nut oils
Date: Sep 10, 2009
Author:
A linear correlation method is proposed for accurate assignments of the 13C{1H} NMR spectra of major fatty acid components in apricot kernel, avocado pear, grapeseed, macadamia nut, mango kernel and marula vegetable oils. This approach, under carefully defined conditions and concentrations, is useful for crowded regions of the NMR spectrum where significant peak overlap occurs.
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Pregnant pause for thought
Date: Sep 1, 2009
Author: David Bradley
NMR spectroscopy has revealed that a chemical compound found in unpasteurised food can be present at unusually high levels in the red blood cells of pregnant women. The compound, ergothioneine, could be used as a biomarker for the potentially fatal condition, pre-eclampsia, which can cause severely raised blood pressure during pregnancy.
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Keeping an eye on anticancer drug
Date: Aug 15, 2009
Author: David Bradley
NMR spectroscopy has been used in structural studies and a novel synthesis of a compound, cyclopamine, which is found in corn lilies and causes lambs born of ewes that eat the lilies to be born with a single eye in the middle of their foreheads. The compound might one day redeem itself as a human anticancer drug.
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T2 relaxation measurement with solvent suppression and implications to solvent suppression in general
Date: Aug 13, 2009
Author:
In the course of implementing various water suppression schemes into the standard CPMG pulse program and evaluating their T2 measurement accuracy, it was discovered that the addition of a spin echo train improves the performance of common water suppression pulse programs, such as WATERGATE or Excitation Sculpting. In favorable cases, lines that are masked by the solvent peak can be recovered.
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