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Two-dimensional J-resolved NMR spectroscopy: review of a key methodology in the metabolomics toolbox

Date: Feb 3, 2010

Author:

Two-dimensional 1H J-resolved (JRES) NMR spectroscopy is widely used in metabolomics studies of plants and animals. This review provides a basic introduction to the technique and then discusses and recommends key strategies for both spectral acquisition and processing. Strategies for implementing JRES spectroscopy into the metabolomics toolbox are then considered, including for metabolic fingerprinting, metabolite identification and metabolite quantification.

Read More thumbnail image: Two-dimensional J-resolved NMR spectroscopy review of a key methodology in the metabolomics toolbox

The long and the long of it

Date: Feb 1, 2010

Author: David Bradley

A novel NMR technique has measured the largest distance between two atomic nuclei using NMR, demonstrating that tritium magic angle spinning NMR could be a promising tool for structural applications in the biological and material sciences.

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Detailed, superficial approach to finding new drugs

Date: Jan 15, 2010

Author: David Bradley

An international team has used NMR spectroscopy to study neglected regions of key cell-surface proteins. They have found that these regions undergo minute conformational changes in response to drugs, a finding that could ultimately prove useful in the design of new drugs for a range of diseases.

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The development of an NMR chemical shift prediction application with the accuracy necessary to grade proton NMR spectra for identity

Date: Jan 13, 2010

Author:

An NMR chemical shift prediction system was developed that enables high throughput automatic grading of NMR Spectra. This system used atom connectivity, stereochemistry, and experimental solvent. The accuracy of the system was demonstrated to estimate proton chemical shifts with an average error of +/-0.16 ppm.

Read More thumbnail image: The development of an NMR chemical shift prediction application with the accuracy necessary to grade proton NMR spectra for identity

NMR test for pneumonia

Date: Jan 1, 2010

Author: David Bradley

The first demonstration of how metabolic analysis using NMR spectroscopy to analyse a urine sample for diagnosis of community-acquired pneumonia has been undertaken. The simple diagnostic could be useful as the incidence of community-acquired pneumonia rises across the globe.

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Boning up on NMR

Date: Dec 15, 2009

Author: David Bradley

Solid-state NMR spectroscopy can analyse intact bone and could lead to atomic-level explorations of how disease and aging affect bone. It could show, for instance, how age-related water loss leads to structural changes.

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Enigmatic viral promotion

Date: Dec 1, 2009

Author: David Bradley

An enigmatic component of human semen, SEVI, semen-derived enhancer of virus infection, boosts infectivity of the human immunodeficiency virus (HIV) which causes AIDS. Since its discovery in 2007, researchers have been hoping to learn more about its structure with the aim of inhibiting its infection-promoting activity; NMR spectroscopy has now produced new clues.

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Absolute NMR for cancer compound

Date: Nov 15, 2009

Author: David Bradley

An international team has developed NMR methodology that allows them to measure Residual Dipolar Couplings in small molecules and so determine their absolute configuration where conventional techniques fail.

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The origins and present status of the radio wave controversy in NMR

Date: Nov 5, 2009

Author:

The origins, history, and present status of the controversy surrounding a quantum description of the NMR signal as being due to radio waves are traced.

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Cancer transition

Date: Nov 1, 2009

Author: David Bradley

Anticancer drugs for treating ovarian and colon cancer could use rare metals as weapons in the battle against these diseases. The presence of unusual metal centres in organometallic compounds presents a novel affront to tumour cells that may even beat cancer cells that have evolved resistance to conventional drugs.

Read More thumbnail image: Cancer transition
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