NMR Knowledge Base / Ezine
Mysterious marine microbe metabolism
Date: Oct 15, 2009
Author: David Bradley
NMR spectroscopy has helped to show that microscopic marine microbes, phytoplankton, are the solution to a ten-year-old mystery about the source of an essential nutrient in the oceans, the phosphonates found in organic phosphorus.
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Putting the squeeze on molecular guests
Date: Oct 1, 2009
Author: David Bradley
Researchers in Germany are working on an unprecedented high-temperature host-guest super molecule, visualised with NMR spectroscopy. The system might be used to study molecules trapped inside the capsule for hydrophobic and confinement effects.
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Monopoles apart
Date: Sep 15, 2009
Author: David Bradley
Four research papers, two of which were published in the journal Science, this week, and two submitted to the physics preprint archive, suggest that a long-sought icon of fundamental physics has finally been discovered - the magnetic monopole. This fundamental research could have enormous potential in materials research, nanotechnology, and eventually instrumentation.
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A novel approach to the rapid assignment of 13C NMR spectra of major components of vegetable oils such as avocado, mango kernel and macadamia nut oils
Date: Sep 10, 2009
Author:
A linear correlation method is proposed for accurate assignments of the 13C{1H} NMR spectra of major fatty acid components in apricot kernel, avocado pear, grapeseed, macadamia nut, mango kernel and marula vegetable oils. This approach, under carefully defined conditions and concentrations, is useful for crowded regions of the NMR spectrum where significant peak overlap occurs.
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Pregnant pause for thought
Date: Sep 1, 2009
Author: David Bradley
NMR spectroscopy has revealed that a chemical compound found in unpasteurised food can be present at unusually high levels in the red blood cells of pregnant women. The compound, ergothioneine, could be used as a biomarker for the potentially fatal condition, pre-eclampsia, which can cause severely raised blood pressure during pregnancy.
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Keeping an eye on anticancer drug
Date: Aug 15, 2009
Author: David Bradley
NMR spectroscopy has been used in structural studies and a novel synthesis of a compound, cyclopamine, which is found in corn lilies and causes lambs born of ewes that eat the lilies to be born with a single eye in the middle of their foreheads. The compound might one day redeem itself as a human anticancer drug.
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T2 relaxation measurement with solvent suppression and implications to solvent suppression in general
Date: Aug 13, 2009
Author:
In the course of implementing various water suppression schemes into the standard CPMG pulse program and evaluating their T2 measurement accuracy, it was discovered that the addition of a spin echo train improves the performance of common water suppression pulse programs, such as WATERGATE or Excitation Sculpting. In favorable cases, lines that are masked by the solvent peak can be recovered.
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Insider fingerprints
Date: Aug 1, 2009
Author: David Bradley
An Italian and German research team has used NMR spectroscopy to fingerprint a person's metabolic phenotype. Their work shows that while the range of metabolic products and their concentrations varies significantly from person to person they are relatively stable over time for each individual.
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A medical tale in the sting
Date: Jul 15, 2009
Author: David Bradley
The venom of the bee, Lasioglossum laticeps, contains three novel antimicrobial compounds known as lasioglossins, which have been structurally characterised by NMR spectroscopy. The compounds offer a new avenue for developing new antibiotics that might defeat drug-resistant bacteria.
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Slick approach to vegetable oil analysis
Date: Jul 1, 2009
Author: David Bradley
Researchers have developed a novel approach to the rapid assignment of carbon-13 NMR spectra to the major components of vegetable oils such as avocado, mango kernel and macadamia nut oils.
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