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Zinc deficiency:Hedgehog activation

Date: May 1, 2015

Author: David Bradley

Zinc deficiency, which is associated with various cancers, can lead to activation of the "Hedgehog" signalling pathway, according to evidence arising from studies that involved solution NMR spectroscopy.

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Harnessing insulation: Magnetic clue

Date: Apr 15, 2015

Author: David Bradley

A subatomic magnetic phenomenon predicted more than sixty years ago has been measured for the first time. The demonstration of van Vleck magnetism could open the door to harnessing topological insulators - hybrid materials that are both conducting and insulating - and may well lead to new approaches to quantum computing, spintronics applications, and much-improved semiconductors.

Read More thumbnail image: Harnessing insulation Magnetic clue

Hot magnets: Homing in on phonons

Date: Apr 1, 2015

Author: David Bradley

A magnetic field can be used to control heat through the manipulation of acoustic phonons, the elementary particles that transmit thermal energy and sound, according to US researchers.

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Journal Highlight: 1H NMR spectroscopy of glioblastoma stem-like cells identifies alpha-aminoadipate as a marker of tumor aggressiveness

Date: Mar 30, 2015

Author: spectroscopyNOW

Metabolite profiles of 42 glioblastoma stem-like cell lines were screened with 1H NMR spectroscopy and compared with human neural progenitor cells from human adult olfactory bulb and from the developing human brain.

Read More thumbnail image: Journal Highlight 1H NMR spectroscopy of glioblastoma stem-like cells identifies alpha-aminoadipate as a marker of tumor aggressiveness

Oily feedstock: NMR tests cosmetic raw materials

Date: Mar 15, 2015

Author: David Bradley

Nuclear magnetic resonance (NMR) spectroscopy has been used to test food industry waste, specifically waste material from fish and oilseed rape, which contains useful proteins and other substances that can be extracted for use in cosmetics and other non-food products that nevertheless require stringent quality and safety controls.

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Journal Highlight: Fertility-associated metabolites in bull seminal plasma and blood serum: 1H NMR analysis

Date: Mar 2, 2015

Author: spectroscopyNOW

A proof-of-principle study has been carried out to identify fertility-associated metabolites in dairy bull seminal plasma and blood serum using proton NMR spectroscopy.

Read More thumbnail image: Journal Highlight Fertility-associated metabolites in bull seminal plasma and blood serum 1H NMR analysis

FAT10 to MAD2, do you copy? NMR clues to inflammatory cancer

Date: Mar 1, 2015

Author: David Bradley

The interaction between two proteins, FAT10 and MAD2, leads to cancers associated with inflammation, including liver (hepatocellular carcinoma) and colorectal cancers. NMR spectroscopy reveals new clues regarding the structure of FAT10 and might lead to innovative ways to disrupt this unique interaction and perhaps inhibit cancer.

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Flu shot: NMR spectroscopy helps with model building

Date: Feb 15, 2015

Author: David Bradley

The combination of experimental data from nuclear magnetic resonance spectroscopy, X-ray crystallography,  cryoelectron microscopy and lipidomics has allowed researchers to build the first complete model of the outer envelope of an influenza A virion.

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Journal Highlight: Nuclear magnetic resonance structure elucidation of peptide b2 ions

Date: Feb 1, 2015

Author: spectroscopyNOW

A strategy has been introduced to elucidate MS fragment ion structures using NMR spectroscopy for the first time, illustrated by the peptide b2 fragment ion.

Read More thumbnail image: Journal Highlight Nuclear magnetic resonance structure elucidation of peptide b2 ions

Functionalised nanocarbons: Chrome-plated NMR spectroscopy

Date: Feb 1, 2015

Author:

Proton NMR (nuclear magnetic resonance) spectroscopy, high-resolution mass spectrometry and X-ray crystallography have been used to probe chromium-centred cycloparaphenylene organometallic rings. The results could allow chemists to define ways to readily functionalize nanocarbons, according to research published in the Journal of the American Chemical Society.

Read More thumbnail image: Functionalised nanocarbons Chrome-plated NMR spectroscopy
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