NMR Knowledge Base / Ezine
Farming phosphorus
Date: Feb 15, 2009
Author: David Bradley
Phosphorus NMR can help distinguish between the nature of organic and non-organic farming and provide clues about how phosphorus from both sources affects waterways and coasts.
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Getting inside bacteria with NMR
Date: Feb 1, 2009
Author: David Bradley
Solid-state nuclear magnetic resonance spectroscopy has been used for the first time to investigate large membrane proteins in bacteria, allowing researchers to investigate exactly how the sensory organs of these single-celled organisms function.
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Bilious NMR
Date: Jan 15, 2009
Author: David Bradley
High-field NMR spectroscopy has been used for the first time to analyse human liver bile, as opposed to gall bladder bile, with a view to improving liver transplant success.
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Electronic structure and biological activity of chosen DDT-type insecticides studied by 35Cl-NQR
Date: Jan 9, 2009
Author:
A correlation between the electronic structure and biological activity of chosen DDT-type insecticides has been analyzed on the basis of the 35Cl-NQR spectroscopy. The 35Cl-NQR resonance frequencies measured at 77K have been correlated with the LD50 parameter that characterizes the biological activity of these insecticides.
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Folding issues
Date: Jan 1, 2009
Author: David Bradley
NMR spectroscopy is helping US chemists work out shorter and simpler routes to protein-based drugs for treating a wide range of illnesses including diabetes, cancer, and hepatitis.
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Untangling Alzheimer molecules
Date: Dec 15, 2008
Author: David Bradley
NMR provides new clues about how a dipeptide molecule blocks the formation of the toxic amyloid beta-peptide aggregates in the mouse brain. The discovery could put paid to the theory that amyloid beta-peptide causes Alzheimer's disease and suggest a therapeutic lead that focus on the real culprit at an earlier stage.
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Organic soil matters
Date: Dec 1, 2008
Author: David Bradley
Could the earth beneath our feet hold the key to climate change? According to scientists at the University of Toronto Scarborough their NMR results show that global warming is changing the molecular structure of organic matter in soil.
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Death proteins and trigger points
Date: Nov 15, 2008
Author: David Bradley
US researchers have used NMR to identify a previously undetected trigger point on a naturally occurring "death protein" that helps the body get rid of damaged or diseased cells. The researchers suggest that their findings may offer a novel target for new drugs that could be used to treat cancer by forcing malignant cells to undergo apoptosis, or cellular suicide.
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Athletic support
Date: Nov 1, 2008
Author: David Bradley
Researchers have used NMR to show that endurance-trained athletes have a higher resting muscle metabolism than couch potatoes. The work suggests that the dissociation of oxidation and adenosine triphosphate (ATP) production could be another route by which exercise improves insulin sensitivity and burns excess energy and may have implications for understanding the development of type 2 diabetes.
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Exploded view
Date: Oct 15, 2008
Author: David Bradley
US researchers have used NMR to study the products of research into a new high explosive material that can nevertheless be melt cast into a charge with any shape.
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