NMR Knowledge Base / Ezine
Parahydrogen induced polarization of barbituric acid derivatives: 1H hyperpolarization studies
Date: Jul 4, 2008
Author:
Parahydrogen induced polarization (PHIP) has turned out to be a versatile technique to obtain hyperpolarized molecules exhibiting strong NMR signals via a chemical approach. In this paper, the authors investigate the PHIP of unsaturated barbiturates (interesting physiologically active compounds) with a standard rhodium catalyst.
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Prions - the Agent Smith of disease
Date: Jul 1, 2008
Author: David Bradley
NMR spectroscopy has revealed significant difference between the infectious and non-infectious form of prions, errant proteins that replicate by converting other proteins into copies of themselves. The finding could lead to new insights into how prions cause brain diseases, such as CJD and Alzheimer's and may one day lead to a way to stop their spread.
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Sniffing out longer-lasting beer
Date: Jun 15, 2008
Author: David Bradley
NMR spectroscopy and a chromatography based sniff test have yielded results that could help brewers improve the flavour and shelf-life and beer thanks to work by scientists in Venezuela. The team has identified alpha-dicarbonyls as important compounds that reduce beer's flavour and point to a new approach to improving shelf life.
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A review with comprehensive data on experimental indirect scalar NMR spin-spin coupling constants across hydrogen bonds
Date: Jun 4, 2008
Author:
Scalar NMR spin-spin coupling constants across hydrogen bonds are fundamental in structural studies and as test grounds for theoretical calculations. Since they are scattered among many articles of different kinds, it seems useful to collect them in the most comprehensive way.
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Sunshine model monomer
Date: Jun 1, 2008
Author: David Bradley
Australian researchers have designed and synthesised a novel indolic compound that can act as a model for the skin pigment eumelanin. Their NMR spectroscopy and X-ray diffraction studies reveal new insights into the biochemistry of eumelanin and the relationship between its chemical structure and its function.
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Characterization of nonderivatized plant cell walls using high-resolution solution-state NMR spectroscopy
Date: May 16, 2008
Author:
A recently described plant cell wall dissolution system has been modified to use perdeuterated solvents to allow direct in-NMR-tube dissolution and high-resolution solution-state NMR of the whole cell wall without derivatization. in this paper the authors describe a method to synthesize 1-methylimidazole-d6 with a high degree of perdeuteration, thus allowing cell wall dissolution and NMR characterization of nonderivatized plant cell wall structures.
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Focusing on quantum forgetfulness
Date: May 15, 2008
Author: David Bradley
Uncontrollable outside influences could undermine the world of quantum computing. Now, researchers have turned to electron spin resonance (ESR) spectroscopy to help them home in on the sources, with a view to avoiding decoherence.
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Hybrid contact
Date: May 1, 2008
Author: David Bradley
A new strategy for creating hybrid materials, part synthetic polymer, part natural protein, has been devised by US researchers. The team at the University of California, Berkeley, used NMR to monitor progress and suggest that such hybrids could exploit the benefits of both components in a wide range of novel applications.
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Absolutely!
Date: Apr 15, 2008
Author: David Bradley
US and Japanese researchers have developed chiral compounds that make it easiler to determine the absolute configuration of an organic compound using X-ray crystallography and proton NMR.
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Characterization of human hair melanin and its degradation products by means of magnetic resonance techniques
Date: Apr 7, 2008
Author:
Melanin granules have been extracted from human Chinese black hairs by either acid hydrolysis or enzymatic digestion, and their chemical structure investigated at the solid state by means of 13C cross polarization magic angle spinning and EPR spectroscopy.
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