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Saucy solution: HIV antivirals

Date: May 15, 2014

Author: David Bradley

US researchers are using nuclear magnetic resonance spectroscopy to help inform their virology efforts in the hope of develop new, potent antiviral agents for the treatment of HIV, human immunodeficiency virus.

Read More thumbnail image: Saucy solution HIV antivirals

Journal Highlight: Next-generation heteronuclear decoupling for high-field biomolecular NMR spectroscopy

Date: May 5, 2014

Author: spectroscopyNOW

A novel low-power, broadband heteronuclear decoupling pulse is presented that generates minimal, ultra-low sidebands for ultra-high-field NMR spectroscopy.

Read More thumbnail image: Journal Highlight Next-generation heteronuclear decoupling for high-field biomolecular NMR spectroscopy

Human herpes virus 4: No bar to understanding

Date: May 1, 2014

Author: David Bradley

NMR spectroscopy has been used to investigate how a viral protein in human herpes virus 4 (also known as Epstein-Barr) regulates the activity of a second essential protein and so reveals a possible new target for the development of antiviral drugs against this common infectious agent.

Read More thumbnail image: Human herpes virus 4 No bar to understanding

Inflammatory spectroscopy: Hearty biomarkers

Date: Apr 15, 2014

Author: David Bradley

A research team in the USA has discovered that elevated levels, as identified by nuclear magnetic resonance spectroscopy, of two recently identified proteins in the body can act as markers for inflammation and thus indicators of the presence of cardiovascular disease.

Read More thumbnail image: Inflammatory spectroscopy Hearty biomarkers

Predicting pre-eclampsia: NMR metabolomics

Date: Apr 1, 2014

Author: David Bradley

Researchers in Norway have found a useful set of biomarkers in urine and serum samples using NMR spectroscopy that are different between women who are not pregnant, those with normal pregnancies, and those with the debilitating and potentially life-threatening condition of pre-eclampsia.

Read More thumbnail image: Predicting pre-eclampsia NMR metabolomics

Journal Highlight: NMR structures of fusion peptide from influenza hemagglutinin H3 subtype and its mutants

Date: Mar 31, 2014

Author: spectroscopyNOW

The structures of the influenza hemagglutinin H3-HAfp23 peptide and its mutants, G1S and G1V, in dodecylphosphatidyl choline micelles were studied by heteronuclear NMR spectroscopy to study the role of its amino acids in the fusion process.

Read More thumbnail image: Journal Highlight NMR structures of fusion peptide from influenza hemagglutinin H3 subtype and its mutants

Targeting PP1: NMR takes aim

Date: Mar 15, 2014

Author: David Bradley

The enzyme PP1 plays a vital role in countless biochemical processes in the body and is the pivot around which many diseases turn. It is so ubiquitous that until now drug development has tended to avoid it because the side effects and complications that arise when it is targeted are too risky. Now, researchers at Brown University, have used NMR spectroscopy and X-ray crystallography to help them focus on how PP1 interacts with other proteins to understand specific behaviour that might nevertheless be...

Read More thumbnail image: Targeting PP1 NMR takes aim

Journal Highlight: 1H and 13C NMR-based sugar profiling with chemometric analysis and antioxidant activity of herbhoneys and honeys

Date: Mar 3, 2014

Author: spectroscopyNOW

1H and 13C NMR spectroscopy coupled with chemometric analysis (PCA and PLS-DA) and antioxidant assays were used to study 25 samples of Polish herbhoneys and honeys.

Read More thumbnail image: Journal Highlight 1H and 13C NMR-based sugar profiling with chemometric analysis and antioxidant activity of herbhoneys and honeys

Spaghetti virus: NMR clues to cancer-causing herpes

Date: Mar 1, 2014

Author: David Bradley

NMR spectroscopy research carried out at Manchester University has revealed that herpes virus proteins are more "spaghetti-like" than previously thought. The discovery hints at possible treatments for a form of the disease that causes the cancer known as Kaposi’s sarcoma.

Read More thumbnail image: Spaghetti virus NMR clues to cancer-causing herpes

HIV target: NMR revelations

Date: Feb 17, 2014

Author:

NMR spectroscopy has been used to home in on a vulnerable point in the HIV viral machinery, the envelope protein, gp41 membrane proximal external region. The research steals a march on other studies for which the protein is inaccessible, potentially leading the way to a vaccine or new targets for antiviral drugs against the disease.

Read More thumbnail image: HIV target NMR revelations
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