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DNA markers and disease: NMR and MS clues

Date: May 1, 2013

Author: David Bradley

Researchers have used NMR spectroscopy and mass spectrometry to help them understand the chemistry associated with modifications to DNA that are associated with autoimmune disease and cancer. The work offers new clues to the behaviour of modified bases and could open up avenues to new therapeutic agents.

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Journal Highlight: Utilizing NMR and EPR spectroscopy to probe the role of copper in prion diseases

Date: Apr 29, 2013

Author: spectroscopyNOW

Current research on the role of copper in the conformational changes associated with prion diseases are reviewed with emphasis on the latest applications of NMR and EPR spectroscopy to probe the interactions of copper with prion proteins.

Read More thumbnail image: Journal Highlight Utilizing NMR and EPR spectroscopy to probe the role of copper in prion diseases

Panacea: Liquid grace or toxic snake oil?

Date: Apr 15, 2013

Author: David Bradley

Proton NMR spectroscopy and energy dispersive X-ray fluorescence (EDXRF) spectroscopy have been used to analyse snake oil, elixirs, panaceas and other quackery found in medicines prescribed from the 18th century onwards. It turns out that many of these often-patented nostrums contained highly dangerous levels of toxic elements including arsenic, mercury and lead, as well as cocaine, heroin and high levels of alcohol.

Read More thumbnail image: Panacea Liquid grace or toxic snake oil

Journal Highlight: NMR quadrupole liouvillians for arbitrary spin: Exact symbolic expressions and perturbation solutions

Date: Apr 1, 2013

Author: spectroscopyNOW

The NMR of quadrupolar nuclei with half-integer spins, which is described by treating the quadrupole interaction with second-order perturbation theory, has been elaborated on by calculating the transitions directly without the requirement of knowing the operators and wavefunctions.

Read More thumbnail image: Journal Highlight NMR quadrupole liouvillians for arbitrary spin Exact symbolic expressions and perturbation solutions

Mouthwash: An anticancer solution

Date: Apr 1, 2013

Author: David Bradley

The active ingredients in some commercially available mouthwash solution, the bisbiguanide oral disinfectants chlorhexidine (Chlorhexamed, Chlorhexal, Periogard, Corsodyl, and Chlorohex) and alexidine (Esemdent) have been in widespread use for many years. Now, 1H,15N-HSQC NMR spectroscopy has been used in studies to investigate the structural changes these compounds can induce that lead to apoptosis in oral cancer cells.

Read More thumbnail image: Mouthwash An anticancer solution

Clearing the airways: Distinguishing smoking-related diseases by NMR

Date: Mar 15, 2013

Author: Steve Down

NMR spectroscopy of the metabolites in exhaled breath condensate can distinguish between airway respiratory diseases induced by smoking, say Italian researchers.

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Life-saving NMR: Septic shock

Date: Mar 15, 2013

Author: David Bradley

NMR spectroscopy could be used to save the lives of children with septic shock by revealing the tell-tale profile of metabolites associated with the severest cases of this condition.

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Journal Highlight: Coupling of a high-resolution monoamine oxidase-A inhibitor assay and HPLC–SPE–NMR for advanced bioactivity profiling of plant extracts

Date: Mar 4, 2013

Author: spectroscopyNOW

A photometric microplate-based high-resolution monoamine oxidase A inhibitor assay was coupled with an HPLC–SPE–tube transfer NMR system for the bioactivity profiling of plant extracts in the search for new antidepressants.

Read More thumbnail image: Journal Highlight Coupling of a high-resolution monoamine oxidase-A inhibitor assay and HPLCSPENMR for advanced bioactivity profiling of plant extracts

Indicator: Beat the Alzheimer's blues

Date: Mar 1, 2013

Author: David Bradley

Methylene blue is well known as a redox indicator in chemical laboratories, but it may also have a role to play in warding off the symptoms of Alzheimer's disease, according to a new study, or perhaps lead to novel drugs for the disorder based on its chemical structure and properties. Mechanistic details of the compound's putative mode of action are revealed in the journal Angewandte Chemie by researchers using nuclear magnetic resonance (NMR) and spectroscopy and other approaches.

Read More thumbnail image: Indicator Beat the Alzheimers blues

Pores for thought: Just shine a light

Date: Feb 15, 2013

Author: David Bradley

Nuclear magnetic resonance spectroscopy and mass spectrometry, among other techniques have been used in work on polymer pores. While, irradiation with light is a wel-established approach to the initiation of polymerization as well as cross-linking (or curing of polymers) during plastics production, researchers in the USA have now demonstrated that light can be used to retroactively increase the size of the pores within a polymer network.

Read More thumbnail image: Pores for thought Just shine a light
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