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Clearing the airways: Distinguishing smoking-related diseases by NMR

Date: Mar 15, 2013

Author: Steve Down

NMR spectroscopy of the metabolites in exhaled breath condensate can distinguish between airway respiratory diseases induced by smoking, say Italian researchers.

Read More thumbnail image: Clearing the airways Distinguishing smoking-related diseases by NMR

Life-saving NMR: Septic shock

Date: Mar 15, 2013

Author: David Bradley

NMR spectroscopy could be used to save the lives of children with septic shock by revealing the tell-tale profile of metabolites associated with the severest cases of this condition.

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Journal Highlight: Coupling of a high-resolution monoamine oxidase-A inhibitor assay and HPLC–SPE–NMR for advanced bioactivity profiling of plant extracts

Date: Mar 4, 2013

Author: spectroscopyNOW

A photometric microplate-based high-resolution monoamine oxidase A inhibitor assay was coupled with an HPLC–SPE–tube transfer NMR system for the bioactivity profiling of plant extracts in the search for new antidepressants.

Read More thumbnail image: Journal Highlight Coupling of a high-resolution monoamine oxidase-A inhibitor assay and HPLCSPENMR for advanced bioactivity profiling of plant extracts

Indicator: Beat the Alzheimer's blues

Date: Mar 1, 2013

Author: David Bradley

Methylene blue is well known as a redox indicator in chemical laboratories, but it may also have a role to play in warding off the symptoms of Alzheimer's disease, according to a new study, or perhaps lead to novel drugs for the disorder based on its chemical structure and properties. Mechanistic details of the compound's putative mode of action are revealed in the journal Angewandte Chemie by researchers using nuclear magnetic resonance (NMR) and spectroscopy and other approaches.

Read More thumbnail image: Indicator Beat the Alzheimers blues

Pores for thought: Just shine a light

Date: Feb 15, 2013

Author: David Bradley

Nuclear magnetic resonance spectroscopy and mass spectrometry, among other techniques have been used in work on polymer pores. While, irradiation with light is a wel-established approach to the initiation of polymerization as well as cross-linking (or curing of polymers) during plastics production, researchers in the USA have now demonstrated that light can be used to retroactively increase the size of the pores within a polymer network.

Read More thumbnail image: Pores for thought Just shine a light

Journal Highlight: How to tickle spins with a Fourier Transform NMR spectrometer

Date: Feb 4, 2013

Author: spectroscopyNOW

Spin tickling can readily be achieved in homonuclear systems with Fourier transform NMR spectrometers by applying short pulses in the intervals between the sampling points.

Read More thumbnail image: Journal Highlight How to tickle spins with a Fourier Transform NMR spectrometer

Orange juice: NMR health test

Date: Feb 1, 2013

Author: David Bradley

The amino acid composition of juice from oranges grown on trees infected with HLB, Huanglongbing, a pathogen that causes citrus greening disease, can now be distinguished from that produced from healthy trees using a new application of NMR spectroscopy.

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MRC Special Issue on NMR of small molecules in anisotropic media

Date: Jan 15, 2013

Author: spectroscopyNOW

Within this supplement issue of the international journal, Magnetic Resonance in Chemistry, experts publish their new NMR methodologies for the analysis of small organic molecules oriented in weak alignment media. An emerging field with room for new discoveries and developments, readers will be inspired to bring this knowledge into their everyday work.

Read More thumbnail image: MRC Special Issue on NMR of small molecules in anisotropic media

Insulin boost: Definitive speculation

Date: Jan 15, 2013

Author: David Bradley

After decades of speculation about exactly how insulin interacts with cells, an international group of scientists (led by NMR pioneer Michael Weiss) has at last demonstrated a mode of action that shows how insulin binds to the cell to allow the cell to transform sugar into energy - and how the insulin molecule then changes shape as a result of this connection.

Read More thumbnail image: Insulin boost Definitive speculation

Journal Highlight: Determination of free fatty acids in edible oils by 1H NMR spectroscopy

Date: Jan 7, 2013

Author: spectroscopyNOW

A novel proton NMR assay for the determination of free fatty acids in edible oils is a suitable alternative to the acid value method.

Read More thumbnail image: Journal Highlight Determination of free fatty acids in edible oils by 1H NMR spectroscopy
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