NMR Knowledge Base / Ezine
Journal Highlight: Does aluminium bind to histidine? An NMR investigation of amyloid β12 and amyloid β16 fragments
Date: Jul 2, 2013
Author: spectroscopyNOW
In an NMR study of the N-terminal amyloid peptide fragments Aβ12 and (Aβ16), non-histidine residues were found to be involved in aluminium binding.
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Liquid study: Reveals tuneable colours
Date: Jul 1, 2013
Author: David Bradley
Researchers in Japan have used NMR spectroscopy to study liquid materials with excellent light stability based on the skeleton of the organic fluorescent dye anthracene that could be used for full-colour tuneable luminescent systems.
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Invisible touch: What's the matter?
Date: Jun 15, 2013
Author: David Bradley
An explanation as to why we cannot detect 85 percent of the predicted mass of the universe has emerged from fundamental particle research carried out in the 1930s. US physicists have now proposed that dark matter, may be composed of Majorana fermions, which are anapoles with a doughnut-shaped electromagnetic field invisible to any known detector technology.
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Journal Highlight: Assessment of higher order structure comparability in therapeutic proteins using nuclear magnetic resonance spectroscopy
Date: Jun 3, 2013
Author: spectroscopyNOW
NMR spectroscopy using a fingerprinting approach has been used to rapidly assess higher order structure comparability in three nonglycosylated proteins spanning a molecular weight range of 6.5–67 kDa.
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Handheld cancer detection: Microfluidics meets NMR
Date: Jun 1, 2013
Author: David Bradley
A handheld device first developed for cancer diagnosis has been adapted to rapidly diagnose tuberculosis (TB) and other bacterial infections. Two papers appearing in the journals Nature Communications and Nature Nanotechnology describe the portable systems that bring together microfluidics technology and NMR.
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Combined effort: Spectroscopic cancer clues under the microscope
Date: May 15, 2013
Author: David Bradley
A combination of atomic force microscopy (AFM) and nuclear magnetic resonance (NMR) spectroscopy could provide oncologists and cancer researchers with a new way to probe how cancer cells spread in the body through metastasis as well as other disease-related processes.
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DNA markers and disease: NMR and MS clues
Date: May 1, 2013
Author: David Bradley
Researchers have used NMR spectroscopy and mass spectrometry to help them understand the chemistry associated with modifications to DNA that are associated with autoimmune disease and cancer. The work offers new clues to the behaviour of modified bases and could open up avenues to new therapeutic agents.
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Journal Highlight: Utilizing NMR and EPR spectroscopy to probe the role of copper in prion diseases
Date: Apr 29, 2013
Author: spectroscopyNOW
Current research on the role of copper in the conformational changes associated with prion diseases are reviewed with emphasis on the latest applications of NMR and EPR spectroscopy to probe the interactions of copper with prion proteins.
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Panacea: Liquid grace or toxic snake oil?
Date: Apr 15, 2013
Author: David Bradley
Proton NMR spectroscopy and energy dispersive X-ray fluorescence (EDXRF) spectroscopy have been used to analyse snake oil, elixirs, panaceas and other quackery found in medicines prescribed from the 18th century onwards. It turns out that many of these often-patented nostrums contained highly dangerous levels of toxic elements including arsenic, mercury and lead, as well as cocaine, heroin and high levels of alcohol.
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Journal Highlight: NMR quadrupole liouvillians for arbitrary spin: Exact symbolic expressions and perturbation solutions
Date: Apr 1, 2013
Author: spectroscopyNOW
The NMR of quadrupolar nuclei with half-integer spins, which is described by treating the quadrupole interaction with second-order perturbation theory, has been elaborated on by calculating the transitions directly without the requirement of knowing the operators and wavefunctions.
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