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Protein dynamics: NMR focuses on GPCRs

Date: Jan 5, 2018

Author: David Bradley

Nuclear magnetic resonance (NMR) spectroscopy has allowed US researchers to peer into the heart of a key protein used in drug design to reveal dynamic structural features that may lead to new ways for targeting disease.

Read More thumbnail image: Protein dynamics NMR focuses on GPCRs

Journal Highlight: Nuclear magnetic relaxation dispersion of murine tissue for development of T1 (R1) dispersion contrast imaging

Date: Jan 1, 2018

Author: spectroscopyNOW

The spin–lattice relaxation rate (R1) dispersion of murine tissues from 0.24 mT to 3 T has been assessed using a combination of ex vivo and in vivo spin–lattice relaxation rate measurements on murine tissue.

Read More thumbnail image: Journal Highlight Nuclear magnetic relaxation dispersion of murine tissue for development of T1 R1 dispersion contrast imaging

One flu over: NMR insights

Date: Dec 15, 2017

Author: David Bradley

When you catch influenza, the virus hijacks the inner workings of your cells to make copies of itself. The copies accumulate in viral buds that then break free from the host cell to infect another host. Researchers at Massachusetts Institute of Technology have now used solid-state nuclear magnetic resonance (NMR) spectroscopy to obtain a clear picture of how these buds pinch off from the host cell membrane.

Read More thumbnail image: One flu over NMR insights

Fluorine pharma: Quality control by NMR

Date: Dec 1, 2017

Author: David Bradley

Routine analysis and quality control of fluorine-containing pharmaceuticals could now be possible with the application of the relatively simple and straightforward technique of fluorine-19 nuclear magnetic resonance (NMR) spectroscopy, according to researchers in Kenya and Germany.

Read More thumbnail image: Fluorine pharma Quality control by NMR

Journal Highlight: 31P NMR of the pyruvate kinase reaction: An undergraduate experiment in enzyme kinetics

Date: Nov 27, 2017

Author: spectroscopyNOW

A simple 31P NMR tube experiment has been developed that allows students to examine the enzyme kinetics and equilibrium constant of the reaction catalyzed by pyruvate kinase.

Read More thumbnail image: Journal Highlight 31P NMR of the pyruvate kinase reaction An undergraduate experiment in enzyme kinetics

Pick up a prion: Solid state NMR spots the differences

Date: Nov 15, 2017

Author: David Bradley

Researchers in the USA have used solid-state nuclear magnetic resonance (NMR) spectroscopy to study the rogue proteins involved in familial human cerebral amyloid angiopathy (CAA). This hereditary neurodegenerative condition is one of the family of prion diseases that afflict mammals and include bovine spongiform encephalopathy (often referred to colloquially as "mad cow disease"), Creutzfeldt-Jakob disease in humans, their equivalents in cats, mice, hamsters and other animals.

Read More thumbnail image: Pick up a prion Solid state NMR spots the differences

Final piece of protein puzzle: NMR tops and tails HIV

Date: Nov 1, 2017

Author: David Bradley

Nuclear magnetic resonance (NMR) spectroscopy has been used to put in place the final piece of the HIV-1 protein structure, the cytoplasmic tail of gp41 protein. The research by a team at the University of Alabama at Birmingham led by Jamil Saad will help scientists better understand how the virus infects human cells and how progeny viruses are assembled and released from infected cells.

Read More thumbnail image: Final piece of protein puzzle NMR tops and tails HIV

Journal Highlight: The C6H6 NMR repository: an integral solution to control the flow of your data from the magnet to the public

Date: Oct 30, 2017

Author: spectroscopyNOW

A powerful toolbox built on recent technologies that runs inside the browser and provides a means to store, share, analyse and interact with original NMR data has been developed under MIT license to facilitate the sharing of NMR data.

Read More thumbnail image: Journal Highlight The C6H6 NMR repository an integral solution to control the flow of your data from the magnet to the public

Spot the difference: NMR technique for drug design

Date: Oct 15, 2017

Author: David Bradley

A powerful new NMR technique DiffErential EPitope mapping by STD NMR spectroscopy (DEEP-STD NMR) is being used by researchers in the UK to reveal the nature of the contact between ligand and protein target with a view to developing new pharmaceuticals with fewer side-effects.

Read More thumbnail image: Spot the difference NMR technique for drug design

New 1.2 GHz NMR Spectrometers - New Horizons?

Date: Oct 3, 2017

Author: Prof. Dr. Harald Schwalbe

The latest ultrahigh-field NMR spectrometers are a huge technological challenge that require large financial investments. In his Guest Editorial written in the July issue of Angewandte Chemie, Harald Schwalbe justifies the need for spectrometers with higher magnetic field strengths. The important results from previous generations of high-field NMR spectrometers are discussed, and research areas are identified that will benefit from the latest spectrometers.

Read More thumbnail image: New 1_2 GHz NMR Spectrometers - New Horizons
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