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Alzheimer's analysed: New clues in brain disease

Date: Nov 15, 2012

Author:

Recent studies have added weight to the idea that amyloid-beta is a causative agent in Alzheimer's disease rather than the plaques formed from these chunks of misfolded peptide that deposit in the diseased brain. Now, European researchers have used REAPDOR solid-state NMR spectroscopy to analyse the hydrogen bonds in the tiny fibrils of amyloid-beta peptide, offering another perspective on this neurodegenerative disorder.

Read More thumbnail image: Alzheimers analysed New clues in brain disease

Journal Highlight: Quantitative NMR: An applicable method for quantitative analysis of medicinal plant extracts and herbal products

Date: Nov 5, 2012

Author: spectroscopyNOW

A quantitative NMR method has been reported for quantitative analysis of three medicinal plant extracts and their herbal products without the need of authentic standards.

Read More thumbnail image: Journal Highlight Quantitative NMR An applicable method for quantitative analysis of medicinal plant extracts and herbal products

3D target: Membrane protein structure

Date: Nov 1, 2012

Author: David Bradley

X-ray crystallography has been used to identify two new small chaperone molecules. The targets may prove useful in developing the first pharmaceutical treatment for the rare but debilitating inherited metabolic disorder Schindler/Kanzaki disease.

Read More thumbnail image: 3D target Membrane protein structure

Fast switch: RNA vs NMR

Date: Oct 15, 2012

Author: David Bradley

Researchers have used NMR spectroscopy to tease out details of the smallest and fastest-known molecular switches composed of ribonucleic acid, RNA. These structures exist only fleetingly and yet look set to be become important targets for the development of new antiviral and antibiotic drugs.

Read More thumbnail image: Fast switch RNA vs NMR

Nobel chemistry: pharma directions

Date: Oct 10, 2012

Author: David Bradley

The Royal Swedish Academy of Sciences has awarded the 2012 Nobel Prize in Chemistry jointly to Robert Lefkowitz of the Howard Hughes Medical Institute and Duke University Medical Center and Brian Kobilka Stanford of the University School of Medicine, Stanford "for studies of G-protein–coupled receptors".

Read More thumbnail image: Nobel chemistry pharma directions

Journal Highlight: 1H-Nuclear magnetic resonance-based metabonomic analysis of brain in rhesus monkeys with morphine treatment and withdrawal intervention

Date: Oct 1, 2012

Author: spectroscopyNOW

Metabolic changes in brain hippocampus and prefrontal cortex of rhesus monkeys were measured by 1H-NMR, coupled with partial least squares and orthogonal signal correction analysis, to study morphine dependence and withdrawal therapy in a model highly related to humans.

Read More thumbnail image: Journal Highlight 1H-Nuclear magnetic resonance-based metabonomic analysis of brain in rhesus monkeys with morphine treatment and withdrawal intervention

Playing protein tag: Repeatable NMR

Date: Oct 1, 2012

Author: David Bradley

Chemists at the University of California San Diego have developed a method that allows them, for the first time, to attach chemical probes on to proteins and remove them again in a straightforward and repeatable cycle. The method will facilitate NMR spectroscopy for metabolic and other research studies.

Read More thumbnail image: Playing protein tag Repeatable NMR

MOFs: NMR reveals inner secrets

Date: Sep 15, 2012

Author: David Bradley

A large international research team from Canada and China has shown for the first time that zinc-67 solid-state NMR spectroscopy could be as useful in analysing the zinc atom centres in a new type of synthetic porous materials known as metal-organic frameworks (MOFs) as its aluminium-based counterpart, aluminium-27 NMR is in studying the more widely known natural porous zeolite minerals.

Read More thumbnail image: MOFs NMR reveals inner secrets

Journal Highlight: Applications of NMR metabolomics to the study of foodstuffs: Truffle, kiwifruit, lettuce, and sea bass

Date: Sep 3, 2012

Author: spectroscopyNOW

The use of NMR to study the metabolomes of foodstuffs of different origin (truffle, kiwifruit, lettuce, sea bass) with different metabolite compositions, processing, and storage procedures, is reviewed.

Read More thumbnail image: Journal Highlight Applications of NMR metabolomics to the study of foodstuffs Truffle kiwifruit lettuce and sea bass

Move like caged hydrogen: Buckyball traps

Date: Sep 1, 2012

Author: David Bradley

Cryogenic NMR spectroscopy and other techniques has been used to investigate how small molecules, including water, are trapped by the all-carbon cages known as fullerenes. The work might open up the possibility of using such caged systems as alternative contrast agents for magnetic resonance imaging.

Read More thumbnail image: Move like caged hydrogen Buckyball traps
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