NMR Knowledge Base / Ezine
Mouthwash: An anticancer solution
Date: Apr 1, 2013
Author: David Bradley
The active ingredients in some commercially available mouthwash solution, the bisbiguanide oral disinfectants chlorhexidine (Chlorhexamed, Chlorhexal, Periogard, Corsodyl, and Chlorohex) and alexidine (Esemdent) have been in widespread use for many years. Now, 1H,15N-HSQC NMR spectroscopy has been used in studies to investigate the structural changes these compounds can induce that lead to apoptosis in oral cancer cells.
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Life-saving NMR: Septic shock
Date: Mar 15, 2013
Author: David Bradley
NMR spectroscopy could be used to save the lives of children with septic shock by revealing the tell-tale profile of metabolites associated with the severest cases of this condition.
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Journal Highlight: Coupling of a high-resolution monoamine oxidase-A inhibitor assay and HPLC–SPE–NMR for advanced bioactivity profiling of plant extracts
Date: Mar 4, 2013
Author: spectroscopyNOW
A photometric microplate-based high-resolution monoamine oxidase A inhibitor assay was coupled with an HPLC–SPE–tube transfer NMR system for the bioactivity profiling of plant extracts in the search for new antidepressants.
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Indicator: Beat the Alzheimer's blues
Date: Mar 1, 2013
Author: David Bradley
Methylene blue is well known as a redox indicator in chemical laboratories, but it may also have a role to play in warding off the symptoms of Alzheimer's disease, according to a new study, or perhaps lead to novel drugs for the disorder based on its chemical structure and properties. Mechanistic details of the compound's putative mode of action are revealed in the journal Angewandte Chemie by researchers using nuclear magnetic resonance (NMR) and spectroscopy and other approaches.
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Pores for thought: Just shine a light
Date: Feb 15, 2013
Author: David Bradley
Nuclear magnetic resonance spectroscopy and mass spectrometry, among other techniques have been used in work on polymer pores. While, irradiation with light is a wel-established approach to the initiation of polymerization as well as cross-linking (or curing of polymers) during plastics production, researchers in the USA have now demonstrated that light can be used to retroactively increase the size of the pores within a polymer network.
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Journal Highlight: How to tickle spins with a Fourier Transform NMR spectrometer
Date: Feb 4, 2013
Author: spectroscopyNOW
Spin tickling can readily be achieved in homonuclear systems with Fourier transform NMR spectrometers by applying short pulses in the intervals between the sampling points.
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Orange juice: NMR health test
Date: Feb 1, 2013
Author: David Bradley
The amino acid composition of juice from oranges grown on trees infected with HLB, Huanglongbing, a pathogen that causes citrus greening disease, can now be distinguished from that produced from healthy trees using a new application of NMR spectroscopy.
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MRC Special Issue on NMR of small molecules in anisotropic media
Date: Jan 15, 2013
Author: spectroscopyNOW
Within this supplement issue of the international journal, Magnetic Resonance in Chemistry, experts publish their new NMR methodologies for the analysis of small organic molecules oriented in weak alignment media. An emerging field with room for new discoveries and developments, readers will be inspired to bring this knowledge into their everyday work.
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Insulin boost: Definitive speculation
Date: Jan 15, 2013
Author: David Bradley
After decades of speculation about exactly how insulin interacts with cells, an international group of scientists (led by NMR pioneer Michael Weiss) has at last demonstrated a mode of action that shows how insulin binds to the cell to allow the cell to transform sugar into energy - and how the insulin molecule then changes shape as a result of this connection.
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Journal Highlight: Determination of free fatty acids in edible oils by 1H NMR spectroscopy
Date: Jan 7, 2013
Author: spectroscopyNOW
A novel proton NMR assay for the determination of free fatty acids in edible oils is a suitable alternative to the acid value method.
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