NMR Knowledge Base / Ezine
MRC Special Issue on NMR of small molecules in anisotropic media
Date: Jan 15, 2013
Author: spectroscopyNOW
Within this supplement issue of the international journal, Magnetic Resonance in Chemistry, experts publish their new NMR methodologies for the analysis of small organic molecules oriented in weak alignment media. An emerging field with room for new discoveries and developments, readers will be inspired to bring this knowledge into their everyday work.
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Insulin boost: Definitive speculation
Date: Jan 15, 2013
Author: David Bradley
After decades of speculation about exactly how insulin interacts with cells, an international group of scientists (led by NMR pioneer Michael Weiss) has at last demonstrated a mode of action that shows how insulin binds to the cell to allow the cell to transform sugar into energy - and how the insulin molecule then changes shape as a result of this connection.
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Journal Highlight: Determination of free fatty acids in edible oils by 1H NMR spectroscopy
Date: Jan 7, 2013
Author: spectroscopyNOW
A novel proton NMR assay for the determination of free fatty acids in edible oils is a suitable alternative to the acid value method.
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Sweet complexity: Sugars and diabetes
Date: Jan 7, 2013
Author: David Bradley
NMR spectroscopy has been used to investigate dicarbonyl sugars formed inside the human body from the natural breakdown of the simple sugar, glucose. The implications for understanding the link with diabetes are discussed.
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Tight fit: Loose fit
Date: Dec 15, 2012
Author:
Advanced NMR techniques have allowed a US team to map the molecular chaperone Hsp70 in different states looking at individual amino acids within the protein as they respond to different sample conditions.
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Journal Highlight: Combined use of filtered and edited 1H NMR spectroscopy to detect 13C-enriched compounds in complex mixtures
Date: Dec 3, 2012
Author: spectroscopyNOW
The 13C background signal can be distinguished from resonances of 13C-enriched xenobiotics by the absence of a 12C component, detected by combined analysis of 13C-filtered and -edited proton NMR spectra.
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Particulate matter: NMR checks on brain cancer
Date: Dec 1, 2012
Author:
NMR relaxometry can be used to detect the minuscule cell particles (microvesicles) that are shed by cancer cells and enter the blood stream. The approach offers the potential for a simple, inexpensive and relatively non-invasive way to diagnose and monitor brain cancer researchers say.
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Alzheimer's analysed: New clues in brain disease
Date: Nov 15, 2012
Author:
Recent studies have added weight to the idea that amyloid-beta is a causative agent in Alzheimer's disease rather than the plaques formed from these chunks of misfolded peptide that deposit in the diseased brain. Now, European researchers have used REAPDOR solid-state NMR spectroscopy to analyse the hydrogen bonds in the tiny fibrils of amyloid-beta peptide, offering another perspective on this neurodegenerative disorder.
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Journal Highlight: Quantitative NMR: An applicable method for quantitative analysis of medicinal plant extracts and herbal products
Date: Nov 5, 2012
Author: spectroscopyNOW
A quantitative NMR method has been reported for quantitative analysis of three medicinal plant extracts and their herbal products without the need of authentic standards.
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3D target: Membrane protein structure
Date: Nov 1, 2012
Author: David Bradley
X-ray crystallography has been used to identify two new small chaperone molecules. The targets may prove useful in developing the first pharmaceutical treatment for the rare but debilitating inherited metabolic disorder Schindler/Kanzaki disease.
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